2Darnell JJ,Kerr IM,Stark GR. Jak-STAT pathways and tran- scriptional activation in response to IFNs and other extracellular signaling proteins. Science,1994. 264(5164):1415-1421.
7Uddin S. The Racl/p38 mitogen-activated protein kinase path- way is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Star proteins. J Biol Chem, 2000,275 ( 36 ):27634-27640.
8Mayer IA. The p38 MAPK pathway mediates the growth inhibitory effeet of interferon-alpha in BCR-ABL-expressing cells. J Biol Chem,2001,276(30):28570-28577.
9Wang WH. Sustained activation of p38 mitogen-activated pro- rein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor(TNF) receptor 1/TNF-expression. Mol Cell Biol,2004,24(23): 10352-10365.
10Chang WW. Suppression of p38 mitogenactivated protein kinase inhibits hepatitis B vires replication in human hepatoma cell:the antiviral role of nitric oxide. J Viral Hepat,2008,15 (7): 490-497.
二级参考文献81
1Yoshimura A , Ohkubo T , Kiguchi T,et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J , 1995 , 14 (12) : 2816-2826.
2Strr R , Willson TA , Viney EM, et al. A family of cytokine inducible inhibitors of signaling. Nature ,1997 ,387(6636) :917-921.
3Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, et al. Negative regulation of cytokine signaling and immune responses by SOCS proteins . Arthritis Res Ther, 2005, 7 (3) : 100-110.
4Endo TA , Masuhara M, Yokouchi M,et al. A new protein containing an SH2 domain that inhibits Jak kinases. Nature , 1997 , 387 ( 6636 ) :921-924.
5Krebs DL , Hilton DJ . SOCS proteins : Physiological Suppressors of cytokine signaling. Cell Sci ,2000,113 (16) :2813-2819.
6Federici M, Giustizieri ML. Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling Ilmmunol, 2002 , 169 ( 1 ) :434"-442.
7Ram PA ,Waxman DJ. Role of the cytokine inducible SH2 protein CIS in desensitization of STATSb signaling by continuous growth hormone. Biol Chem,2000 ,275 (50) :39487-39496.
8Sasaki A, Yasukawa H, Shouda T, et al. CIS3/SOCS-3 Suppresses EPO signaling by binding the EPO receptor and JAK2 [J]. Bio Chem ,2000,275 ( 38 ) :299338-299347.
9O'Shea JJ , Gadina M, Schreiber. Cytokine signaling in 2002 : new surprises in the Jak/Star pathway. Cell ,2002 ,109 Suppl :S121- 131.
10Ye Chen, Mark M.W. Chang, Rima Darwiche,et al. Severe Pancreatitis with Exocrine Destruction and Increased Islet Neogenesis in Mice with Suppressor of Cytokine Signaling-1 Deficiency . Am J Pathol, 2004 ,165(3) : 913-921.