手术切除联合射频消融治疗结肠癌肝转移疗效分析

Efficacy of radiofrequency ablation after resection of colorectal caicinomain patients with liver metastases

目的探讨手术联合射频消融治疗结肠癌肝转移患者的治疗效果。方法对2008年1月至2014年3月我科诊治的结肠癌肝转移接受结肠癌根治术和肝内肿瘤灶切除治疗的17例和结肠癌根治术后对肝内肿瘤行射频消融（RFA）治疗的12例患者的临床资料进行回顾性分析。绘制Kaplan—Meier生存曲线，进行生存分析。结果单纯手术治疗的17例患者均于术后20个月内死亡，平均生存时间为（13．412±0．912）月，而手术联合射频消融治疗的12例患者随访6—28个月，平均生存时间为（18．496±2．139）月（P〈0．05）；RFA治疗后患者均出现不同程度的恶心、呕吐、胸闷、右上腹痛、发热，血清ALT和AST轻度升高。结论手术联合射频消融治疗结肠癌肝转移是一种可行的、安全的、有效的方法，可以明显延长患者的生存期。

Objective To investigate the efficacy of radiofrequency ablation after resection of colorectal caicinomain patients with liver metastases. Methods 17 patients with colorectal liver metastases had radical operation and hepatolobectomy and 12 had radical operation and radiofrequency ablation （RFA） from January 2008 to March 2014 in our series. Their clinical materials was retrospectively analyzed, and the survival curve was drawn by the Kaplan Meier. Results All the patients in radical operation and hepatolobectomy died within 20 months after surgery,and the average survival time was （13.412±0.912） months. The patients receiving RFA was followed-up for 6 to 28 months,and the average expected survival time was （18.496±2.139） months,which was significantly longer than in hepatolobectomy group（P〈0.05）. Conclusion The radical operation and radiofrequency ablation for treating colorectal liver metastases is feasible,safe and effective, and it can obviously prolong the patient＇ s survivals.