早期姑息治疗在晚期转移性乳腺癌初治中的临床意义

The clinical significance of early palliative care in previously untreated patients with advanced metastatic breast cancer

目的探讨早期姑息治疗在晚期转移性乳腺癌初治中的临床意义。方法选取2011-07-2014-12该院收治的首诊转移性乳腺癌患者53例,随机分为治疗组27例和对照组26例。治疗组采用早期姑息治疗加标准化疗,对照组仅采用标准化疗。两组患者治疗前后均接受医院焦虑抑郁量表（HADS）和病人健康问卷（PHQ-9）评估,并观察两组患者总生存期。结果治疗组HADS（D）和PHQ-9评分降低程度明显大于对照组,差异有统计学意义（P〈0.05）。治疗组和对照组中位总生存时间分别为29.0个月和23.5个月,差异有统计学意义（P〈0.05）。结论早期姑息治疗可提高转移性乳腺癌患者生存质量,延长生存期。

Objective To observe the clinical significance of early palliative care in previously untreated patients with advanced metastatic breast cancer. Methods Fifty-three patients with metastatic breast cancer confirmed by pathology and imaging were collected from July 2011 to December 2014,and were randomly divided into two groups. The treatment group（ n = 27） received early palliative care and standard chemotherapy,while the control group（ n = 26） was treated with chemotherapy alone. The levels of Hospital Anxiety and Depression Scale（ HADS）and the Patient Health Questionnaire（ PHQ-9） were compared between the two groups before and after the treatment,and the overall survival was also observed. Results HADS（ D） and PHQ-9 scores in the treatment group were significantly lower than those in the control group（ P〈0. 05）. The median overall time of the treatment group（ 29. 0months） was significantly longer than that of the control group（ 23. 5 months）（ P〈0. 05）. Conclusion Early palliative care improves the quality of life in patients with metastatic breast cancer,and prolongs their overall survival.