Hcy CysC RBP在动脉粥样硬化中的临床意义

Clinical application value of Hcy,CysC and RBP in atherosclerotic diseases

目的探讨血清同型半胱氨酸(Homocysteine,Hcy)、胱抑素C(Cystatin C,Cys C)、视黄醇结合蛋白(retinol binding protein,RBP)在动脉粥样硬化中的临床意义。方法通过测定冠心病32例、脑梗死64例、颈动脉粥样硬化120例和健康对照组200名的血清Hcy、Cys C和RBP浓度水平,比较分析其在不同动脉粥样硬化疾病中的临床意义。结果冠心病组、颈动脉粥样硬化组、脑梗死组血清Hcy、Cys C和RBP高于健康对照组,Hcy、Cys C差异有统计学意义(P<0.05)。结论 Hcy、Cys C和RBP水平的升高与冠心病的发生有关,有可能是脑梗死的重要危险因素,观察Hcy、Cys C和RBP水平变化对冠心病、脑梗死及动脉粥样硬化早期预防、诊治及预后评估具有一定临床意义。

Objective To study the association between homocysteine（ Hcy）,cystatin C（ Cys C）,and retinol binding protein（ RBP） and atherosclerotic diseases,and to explore their clinical applications of prevention,diagnosis and prognosis in atherosclerotic diseases. Methods The levels of serum Hcy,Cys C and RBP were analyzed in32 patients with coronary heart disease（ CHD）,in 64 patients with cerebral infarction,in 120 patients with carotid atherosclerosis,and in 200 healthy controls,respectively. The results were analyzed and compared among different groups of patients with different diseases. Results The levels of serum Hcy,Cys C and RBP were significantly higher in the patients with coronary heart disease,crebral infarction,and carotid atherosclerotic than those in the healthy controls. Conclusion There is a correlation between the elevated levels of serum Hcy,Cys C,RBP and atherosclerotic diseases,indicating that they might be used as laboratory indicators for the prevention,diagnosis,and prognosis of atherosclerotic diseases.