期刊文献+

Hcy CysC RBP在动脉粥样硬化中的临床意义 被引量:14

Clinical application value of Hcy,CysC and RBP in atherosclerotic diseases
下载PDF
导出
摘要 目的探讨血清同型半胱氨酸(Homocysteine,Hcy)、胱抑素C(Cystatin C,Cys C)、视黄醇结合蛋白(retinol binding protein,RBP)在动脉粥样硬化中的临床意义。方法通过测定冠心病32例、脑梗死64例、颈动脉粥样硬化120例和健康对照组200名的血清Hcy、Cys C和RBP浓度水平,比较分析其在不同动脉粥样硬化疾病中的临床意义。结果冠心病组、颈动脉粥样硬化组、脑梗死组血清Hcy、Cys C和RBP高于健康对照组,Hcy、Cys C差异有统计学意义(P<0.05)。结论 Hcy、Cys C和RBP水平的升高与冠心病的发生有关,有可能是脑梗死的重要危险因素,观察Hcy、Cys C和RBP水平变化对冠心病、脑梗死及动脉粥样硬化早期预防、诊治及预后评估具有一定临床意义。 Objective To study the association between homocysteine( Hcy),cystatin C( Cys C),and retinol binding protein( RBP) and atherosclerotic diseases,and to explore their clinical applications of prevention,diagnosis and prognosis in atherosclerotic diseases. Methods The levels of serum Hcy,Cys C and RBP were analyzed in32 patients with coronary heart disease( CHD),in 64 patients with cerebral infarction,in 120 patients with carotid atherosclerosis,and in 200 healthy controls,respectively. The results were analyzed and compared among different groups of patients with different diseases. Results The levels of serum Hcy,Cys C and RBP were significantly higher in the patients with coronary heart disease,crebral infarction,and carotid atherosclerotic than those in the healthy controls. Conclusion There is a correlation between the elevated levels of serum Hcy,Cys C,RBP and atherosclerotic diseases,indicating that they might be used as laboratory indicators for the prevention,diagnosis,and prognosis of atherosclerotic diseases.
出处 《中国临床新医学》 2016年第5期417-420,共4页 CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词 同型半胱氨酸 胱抑素C 视黄醇结合蛋白 Homocysteine(Hcy) Cystatin C(Cys C) Retinol binding protein(RBP)
  • 相关文献

参考文献19

  • 1王燕华.颈动脉粥样硬化、狭窄与短暂性脑缺血发作的相关性研究[J].中国临床医生杂志,2013,41(9):34-35. 被引量:11
  • 2Bhatt DL, Steg PG, Ohman EM, et al. International prevalence, rec- ognition, and treatment of cardiovascular risk factors in outpatients with athernthrombosis [J]. JAMA, 2006, 295(2): 180- 189.
  • 3各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33008
  • 4Park SY, An SA, Lee HB, et al. Different impact of hyperhomocys- teinemia on cerebral small vessel ischemia and cervico-cerebral atherasclemsisin non-stroke individuals [ J ]. Thmmb Res, 2013,131 (1) :e12.
  • 5Goldstein LB, Bushnell CD, Adama R J, et al. Guidelines for the pri- mary prevention of stroke : a guideline for heahhcare professionals from the American heart association/American stroke association [ J ]. Stroke,2011,42 ( 2 ) :517 - 584.
  • 6Xu H, Liu C, Wang Q. Plaque image characteristics, hyperhomocys- teinemia, and gene polymorphism of homocysteine metabolism-related enzyme( MTHFR C677T) in acute coronary syndromel . Cell Bio- chem Biophys,2013,66 (2) :403 - 407.
  • 7Zhu J, WangX, Chen J,et al. Reduced number and activity of circu- lating endothelial progenitor cells from patients with hyperhomocys- teinemia [ J ]. ArCh Med Res, 2006,37 ( 4 ) :484 - 489.
  • 8Sun Y, Chien KL, Hsu HC, et al. Use of serum homocysteine to predict stroke,coronary heart disease and death in ethnic Chinese. 12-year prospective cohort study [ J ]. Cire J ,2009,73 ( 8 ) : 1423 - 1430.
  • 9Nouroozi S, Biglary H, Haghighi B, et al. Development of flow injec- tion spectrofluorimetrie detection system for the determination of ho- moeysteine[ J]. J Fluorese, 2012, 22( 1 ) :365 - 371.
  • 10Martf-Carvajal A J, Sola I,Lathyris D, et al. Homocysteine-lowering interventions for preventing cardiovascular events[ J]. Coehrane Da- tabase Syst Rev, 2013, 1 :CD006612.

二级参考文献5

共引文献33016

同被引文献110

引证文献14

二级引证文献49

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部