冠状动脉斑块不稳定与炎性生化标记物的相关性研究

Study on Association of vulnerable plaque and biomarkers

全世界范围内冠心病发病率呈逐年上升趋势,特别是在急性冠状动脉综合征和心源性猝死患者中无症状人群占很大比重,因此强调冠心病的二级预防意义重大,目前还缺乏对这部分人群有效的监测手段。研究证实绝大多数的急性冠脉事件的发生是由斑块的稳定性而非管腔的狭窄程度决定的。粥样硬化病变是一种炎性病变,炎性因子的作用贯穿病变始终,且病变的发展也不是一个线性的过程,期间受到多种因素的影响和调控。已有研究表明监测外周血中生化标记物水平可预测粥样斑块的进展和近期不良心血管事件的发生。

The incidence of CHD in worldwide increases year by year and it has become one of the main causes of death in developed and developing countries. An asymptomatic population accounts for a large proportion in patients with acute coronary syndrome and sudden cardiac death. So it plays a big significance in the secondary prevention of coronary heart disease, but few effective monitoring methods were found to deal with it. Studies reveal that malignant cardiac events were not result from stenosis degree of lumens but rather vulnerability of plaques. Atherosclerosis is a nonlinear chronic inflammatory process, a variety of cytokines involved. Studies show that levels of serum biomarkers are powerful predictors for lesion progression and prognosis.