微RNA调控肿瘤多药耐药机制的研究进展

Research progresses of mechanisms for the regulation of tumor cell multi-drug resistance by miRNA

微RNA(mi RNA)作为真核生物重要的基因表达调控分子,是肿瘤耐药调控机制中的重要构成部分。mi RNA对靶基因的异常调控可以通过膜受体介导药物外排、药物靶点改变、细胞凋亡途径受阻、DNA修复能力改变等多种方式参与多药耐药调控机制。此外,mi RNA调控肿瘤干细胞生长分化与通过激发保护性自噬来诱导多药耐药的研究领域也有重要进展。该文就mi RNA调控肿瘤细胞多药耐药机制的研究进展作一综述。

MicroRNA（ miRNA） is a vital regulator for gene expression in eukaryotes, as well as an important com ponent in the regulatory mechanism of tumor drug resistance. miRNA can abnorm ally regulate target genes through mem brane receptor-m ediated drug efflux, alteration of drug targets, block of cell apoptotic pathw ays,and change in DNA repair ability,etc., thus involving in the regulatory mechanism of multi-drug resistance.Im portant research advances in the regulation of grow th and differentiation of cancer stem cells and the induction of multi-drug resistance via triggering the protective autophage by miRNA have been achieved. This paper review s recent research progresses of m echanism s for the regulation of tumor cell multi-drug resistance by miRNAs.