摘要
目的:分析2009-2014年中山大学附属惠州医院临床分离鲍曼不动杆菌的分布特征及耐药性演变。方法:收集中山大学附属惠州医院2009-2014年临床分离的1746株鲍曼不动杆菌,用VITEK2系统进行细菌鉴定;AST GN16药敏板进行MIC药敏试验;用WHONET5.6软件结合医院临床病案系统分析耐药性。结果:自2011年来,鲍曼不动杆菌检出率逐年增加,主要集中在ICU、儿科、神经外科及呼吸内科病房的呼吸道标本;鲍曼不动杆菌对常用抗生素耐药性呈上升趋势,其中ICU对亚胺培南耐药率逐年上升明显,2013-2014年,ICU病房亚胺培南耐药率分别达到了75.0%和68.6%。结论:2009-2014年本院鲍曼不动杆菌对常用抗生素的耐药性增加明显,ICU鲍曼不动杆菌菌株的耐药率明显高于全院平均水平,亚胺培南耐药问题严峻。
Objective： To analyze the clinical distribution and drug-resistant characteristics of acinetobacter baumannii isolated from Huizhou Central Affiliated hospital of Sun Yat-sen University during 2009-2014.Method： 1746 acinetobaeter baumannii strains were isolated from our hospital during 2009-2014. The bacteria were identified by VITEK2 compact system, the minimum inhibitory concentration（MIC） was determined by AST GN16 drug sensitive plate, the results were analyzed by WHONETS.6 software.Result： Since 2011, the detection rate of acinetobaeter baumannii increased year by year, which mainly were the respiratory specimen of patients in ICU, pediatrics, neurosurgery and department of respiratory medicine.Acinetobacter baumannii showed increasing drug- resistant to almost all of the antibiotics, the imipenern resistance had increased year by year, imipenem resistance of the ICU in 2013 and 2014 were 75.0% and 68.6% , respectively.Conclusion： The isolates of our hospital showed high drug-resistant to all kinds of antibiotics during 2009-2014, especially those strains isolated from ICU.Imipenem resistance has become a severe problem.
出处
《中外医学研究》
2016年第15期72-74,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广东省惠州市科技局基金资助项目(项目编号:20150801)
关键词
鲍曼不动杆菌
耐药性
抗菌药物
Acinetobacter baumannii
Drug resistance
Antibiotic drug effects
