炎琥宁与利巴韦林治疗小儿手足口病疗效和安全性

The Efficacy and Safety of Yanhuning and Ribavirin in the Treatment of Children with Hand Foot and Mouth Disease

目的:探讨炎琥宁与利巴韦林治疗小儿手足口病疗效和安全性。方法:回顾性分析2012年1月-2014年1月笔者所在医院收治的72例小儿手足口病患儿的临床资料。根据治疗方法不同,将患者分为观察组和对照组,观察组采用炎琥宁联合利巴韦林治疗,对照组采用利巴韦林治疗。比较两组治疗效果及不良反应发生情况。结果:观察组患儿手足皮疹消退时间、口腔溃疡消退时间及退热时间均明显短于对照组,临床总有效率为88.89%,明显高于对照组的72.22%,差异均有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:采用炎琥宁联合利巴韦林治疗小儿手足口病,可以增强病毒的杀灭效果,提高机体免疫力,且不良反应少,值得临床推广应用。

Objective： To investigate the curative effect and safety of Yanhuning and Ribavirin in the treatment of children with hand foot and mouth disease.Method： The clinical data of 72 children with hand foot and mouth disease in our hospital from January 2012 to January 2014 were retrospectively analyzed. They were divided into observation group and control group.The observation group was given Yanhuning and Ribavirin for treatment, the control group was given Ribavirin.The treatment effect and the incidence of adverse reactions were compared between the two groups.Result： The rash subsided time, oral ulcer subsided time and cooling time of the observation group were significantly lower than those of the control group, the total effective rate of the observation group was 88.89%, significantly higher than 72.22% of the control group, the differences were statistically significant（P〈0.05）.The difference in the incidence rate of adverse reactions between the two groups was not statistically signifieant（P〉0.05）.Conclusion： Yanhuning combined with Ribavirin in the treatment of children with HFMD can enhance the virus killing effect, improve immunity , and lead to less adverse reactions, it is worthy of clinical application.