厚朴皮、叶、花水提物对小鼠胃肠动力作用的比较研究

COMPARATIVE STUDY ON THE GASTROINTESTINAL MOTILITY OF MAGNOLIA OFFICINALIS BARK, LEAF, FLOWER WATER EXTRACT IN MICE

目的探讨厚朴皮、叶、花对小鼠胃排空及肠推进运动的影响。方法采用胃排空、小肠推进运动实验法,观察高、低剂量厚朴皮、叶、花水提物对小鼠胃排空及小肠推进运动的影响。结果厚朴干皮、根皮、枝皮、叶水提物高、低剂量均能促进胃排空和肠推进运动,与蒸馏水对照组比较差异显著(P<0.01,P<0.05);厚朴根皮、枝皮、叶水提物组与相对应剂量厚朴干皮水提物组比较,差异无统计学意义(P>0.05)。结论厚朴干皮、根皮、枝皮、叶水提物均具有促进胃排空、肠推进运动的作用,且厚朴根皮、枝皮、叶可代替厚朴干皮用于胃肠促动。

Objective： To investigate the gastric emptying and intestinal propulsive movement of Magnolia officinalis bark, leaf, flower in mice. Methods： By using the gastric emptying and intestinal propulsive movement, to observe the gastric emptying and intestinal propulsive movement of high and low doses of M. officinalis bark, leaf, flower water extract. Results： High and low doses of M. officinalis stem, root and branch bark, leaf water extracts could promote the gastric emptying and intestinal propulsive movement, compared with the distilled water control group, the difference was statistically significant（P〈0.01, P〈0.05）; high and low doses of M. officinalis root bark, branch bark, leaf water extract with the corresponding doses of stem bark water extract had no statistical significance（P〈0.05）. Conclusion： M. officinalis stem, root and branch bark, leaf water extract could promote gastric emptying and intestinal propulsive movement, its root bark, branch bark, leave could replace stem bark for gastrointestinal propulsive movement.