垂体泌乳素腺瘤的中西医研究进展

Progress of Research on Development of Chinese and Western Medicine for Pituitary Prolactin

垂体泌乳素腺瘤是最常见的垂体肿瘤,约占垂体腺瘤的40%~60%[1]。是一种良性肿瘤,极少威胁人的生命。由垂体泌乳素细胞瘤分泌过量泌乳素（PRL）引起的内分泌疾病,多见于20~40岁的女性,男性少见。青年女性典型症状为溢乳闭经综合征。溢乳常伴闭经。男性症状为不育,性功能减退。有临床症状的泌乳素微腺瘤一般不会长成大腺瘤,部分腺瘤有侵袭性,出现腺瘤增大。发病机制是一个多基因共同参与复杂的过程。中医认为本病病位在肝脾肾,与肝、脾、肾的关系密切,肝肾阴虚,肾精不足为本。气滞、血瘀、痰凝、湿热、毒聚为标。

Pituitary adenoma is the most common pituitary tumor,accounting for 40% ~ 60%[1]. It is a benign tumor that rarely threatens human life. The endocrine diseases caused by excess prolactin（ PRL） secretion by the pituitary prolactin secreting cells are more common in women aged 20- 40 years and rare in men. The typical symptoms of young women are galactorrhea- amenorrhea syndrome. Galactorrhea is associated with amenorrhea. Male symptom is sterile and the sexual function drops. The clinical symptoms of the prolactin micro adenoma usually do not grow into a large adenoma and some adenomas are invasive. There is an increase in adenoma. The pathogenesis is a complex process of multiple genes. Chinese medicine believes that this disease locates in the liver and spleen and is closely related with liver,spleen and kidney. Liver- kidney Yin deficiency and kidney essence insufficient are the root. Qi stagnation,blood stasis,phlegm,damp heat and toxin are the causes.