细胞学联合人乳头状瘤病毒检测筛查宫颈病变

Cytology Combined Human Papilloma Virus Screening Cervical Lesion

目的探讨宫颈病变采用液基超薄细胞学技术(TCT)联合人乳头状瘤病毒(HC2)检测筛查效果。方法本次选取我院妇科在2014年1至12月就诊的1010例患者,行TCT检测,结果有异常者行HC2检测,并分析结果。结果本次选取的1010例患者行TCT检查,异常涂片100例,占9.9%。其中不典型鳞状细胞(ASCUS)62例,占62%;鳞状上皮内低度病变(LSIL)28例,占28%;鳞状上皮内高度病变(HSIL)7例,占7%;鳞状细胞癌3例,占3%。异常涂片100例,行HC2检测,HPV阳性:高危型HPV检测值≥1 pg/m L;阴性:检测值<1 pg/m L。不典型鳞状细胞62例中,HPV阳性率为62.9%;鳞状上皮内低度病变28例中,HPV阳性率为92.9%;鳞状上皮内高度病变7例中,HPV阳性率为85.7%。结论宫颈病变诊断时,采用液基细胞学与高危型人乳头状瘤病毒检测联合,可明显提高特异性和敏感度,是对宫颈癌防治的关键,联合两项检查兼用,为最有效的筛查宫颈癌的方法。

Objective To study the cervical lesions with liquid ultra- thin cytology technique（ TCT） in combination with human papilloma virus（ HC2） screening effect. Methods The selection of the hospital of department of gynaecology in 2014 of 1010 cases of patients 1- December,TCT detection,the result is abnormal,HC2 detection,and the results of the analysis. Results The selection of TCT examination in 1010 patients,100 cases of abnormal smear,accounting for 9. 9%. With atypical squamous cells（ ASCUS） in 62 cases,accounting for 62%; Squamous intraepithelial low- grade lesions（ LSIL）,28 cases（ 28%）; Height of squamous intraepithelial lesion（ HSIL）,7 cases（ 7%）; Squamous cell carcinoma（ 3 cases）,accounting for 3%. 100 cases of abnormal smear line HC2 detection,HPV positive： a high- risk type HPV detection value 1 or more pg / m L; Negative： values〈 1 pg / m L. In62 patients with atypical squamous cells,HPV positive rate is 62. 9%; Squamous intraepithelial low- grade lesions in 28 cases,HPV positive rate is 92. 9%; Height of squamous intraepithelial lesions in 7 cases,HPV positive rate was 85. 7%. Conclusion Cervical disease diagnosis,will use the liquid based cytology and joint type of high- risk human papilloma virus detection,can obviously increase the degree of specific and sensitivity,is the key of cervical cancer prevention and control,combined the two check Jiao pointed to use,for the most effective method of screening for cervical cancer.