钙化性主动脉瓣狭窄病理机制及治疗进展

Pathogenesis and treatment of calcific aortic valve stenosis

主动脉瓣狭窄是临床上比较常见的心脏瓣膜病,其主要的病因是主动脉瓣膜钙化。随着人口老龄化的加剧,钙化性主动脉瓣膜病的发病率也不断的增加,因此,过去20多年中,钙化性主动脉瓣膜狭窄一直被认为是一种退行性病变,然而随着近年的研究进展,大量的证据表明,钙化性主动脉瓣膜病是一个活跃的病理过程,其与动脉粥样硬化有相同的风险因素和病理生理特点。本文主要对近年来钙化性主动脉瓣膜病发病机制及治疗进展的研究做一综述。

Aortic stenosis is clinically more common valvular heart disease, and the main cause is aortic valve calcification. With the increase in aging of the population, caleific aortic valve disease incidence also increased continuously. Therefore, during the past 20 years, ealcific aortic valve stenosis has been considered as a degenerative disease, but with research progress in recent years, a large amount of evidence indicates that ealcifie aortic valve disease is an active disease process similar to that of athero- sclerosis with the same risk factors and pathophysiologieal features. This paper summarizes the main research on the progression of the pathogenesis of calcific aortic valve disease and treatment in recent years.