脑出血后发生迟发性脑水肿的相关危险因素分析

The analysis of the related risked factors for delayed cerebral edema after intracerebral hemorrhage

目的探讨脑出血后发生迟发性脑水肿的相关危险因素。方法回顾性分析本院神经内科2012年7月~2014年6月158例非手术治疗的脑出血患者的临床资料,根据患者脑水肿情况分为迟发性脑水肿组（观察组73例）和非迟发性脑水肿组（对照组85例）,对可能影响脑出血后发生迟发性脑水肿的因素危险因素进行单因素和多因素Logistical回归分析。结果单因素分析表明2组患者年龄、高血压和吸烟史、美国国立卫生研究卒中量表（National Institutes of Health Stroke Scale,NIHSS）评分、血糖值、纤维蛋白原、基质金属蛋白酶9（Matrix Metalloproteinases 9,MMP-9）、出血量有明显的差异（P〈0.05）;多因素Logistical回归分析表明纤维蛋白原,MMP-9,NIHSS评分、血糖水平及出血量是脑出血后发生迟发性脑水肿的独立危险因素。结论纤维蛋白原,MMP-9,NIHSS评分,血糖水平及出血量是脑出血后发生迟发性脑水肿的独立危险因素。

Objective To analyse the related risked factors for delayed cerebral edema after intracerebral hemorrhage.Methods The clinical data of 158 patients with intracerebral hemorrhage treaded with conservative treatment in our hospital from July 2012 to June 2014 were analyzed retrospectively.According to the cerebral edema features,patients were divided into delayed cerebral edema group（observation group including 73cases）and without delayed cerebral edema group（control group including 85 cases）.All relative risked factors associated with delayed cerebral edema were analyzed by the univariate analysis and multiple logistical regression analysis step by step.Results The result of univariate analysis showed that the differences of age,the history of hypertension and smoking,NIHSS scores,the value of blood glucose,fibrinogen,matrix metalloproteinases 9 and hematoma volume between two groups were statistically significant（P〈0.05）.Multivariate Logistical regression analysis showed that fibrinogen,matrix metalloproteinases 9,NIHSS scores,the value of blood glucose and the hematoma volume were the independent risked factors for delayed cerebral edema after intracerebral hemorrhage.Conclusion Fibrinogen,matrix metalloproteinases 9,NIHSS scores,the value of blood glucose and the hematoma volume were the independent risked factors for delayed cerebral edema after intracerebral hemorrhage.