奥卡西平与丙戊酸钠治疗儿童良性癫痫伴中央-颞区棘波疗效及安全性评价

The efficacy and safety of oxcarbazepine and valproate in treatment of child benign epilepsy with centro-temporal spike

目的比较奥卡西平和丙戊酸钠单药治疗儿童良性癫痫伴中央-颞区棘波(benign childhood epilepsy with centro-temporal spike,BECTs)的疗效及安全性。方法对新诊断的BECTs患儿随机采用口服奥卡西平和丙戊酸钠治疗,随访发作情况、监测不良反应,复查脑电图(electroencephalography,EEG),随访时间6个月。结果奥卡西平组和丙戊酸钠组各30例,治疗前两组年龄、性别、病程、发作频率、发作形式、EEG表现差异无统计学意义(P>0.05)。奥卡西平组发生不良反应8例(26.67%)。发作完全控制20例,有效7例,无效3例,总有效率90.0%。治疗6个月时EEG正常19例(63.33%),好转8例(26.67%),无变化3例(10.0%);丙戊酸钠组发生不良反应7例(23.33%)。发作完全控制18例,有效8例,无效4例,总有效率86.67%。治疗6个月时EEG正常16例(53.33%),改善10例(33.33%),无变化4例(13.33%)。治疗后两组间不良反应发生率、疗效及EEG改善差异无统汁学意义(P>0.05)。结论奥卡西平与丙戊酸钠单药治疗新诊断的BECTs发作皆有较好疗效,不良反应、耐受性也无明显差异。

Objective To evaluate the therapeutic effect of oxcarbazepine（OXC） and valproate（VPA） in treatment of benign childhood epilepsy with centro-temporal spike（BECTs）. Methods Children diagnosed with BECTs were randomly divided into two gorups： OXC and LEV group. Seizure, adverse drug effect, EEG（electroencephalography, EEG） were followed, and the follow time was about for 6 months. Results Age, gender, duration, frequency of seizure, the ways of seizure and EEG were no statistically significant difference between two groups（P〉0.05）. In OXC group, There were 8 cases who got adverse reactions. The symptoms of 20 cases in 30 cases were completely controlled. There were 7 cases whose seizure were reduced while 3 cases failed to OXC treatment. Total effective rate was 90%. After 6 months of treatment, EEG in 19 cases became normal. There were 8 cases who got better while there were 3 cases who did not changed. In VPA group, There were 7 cases who were observed adverse reactions, There were 18 cases in 30 cases whose symptoms were completely controlled. There were 8 cases whose seizure were reduced while there were 4 cases who failed to OXC treatment. Total effective rate was 86.67%. After 6 months of treatment, EEG in 16 cases were normal. There were 10 cases getting better and 4 cases whose symptoms did not changed. The incidence of adverse reactions, efficacy and improvement of EEG were not different between two groups after treatment. Conclusion OXC and VPA in the treatment of newly diagnosed BECTs had the same effect.