新疆兵团库尔勒地区TCT和HPV-DNA检测在宫颈癌普查工作中的应用现状及临床意义

Application Status and Clinical Significance of Cervical Cancer Screening in TCT and HPV-DNA in Xinjiang Production Korla District

目的探讨新疆兵团库尔勒地区TCT和HPV-DNA检测在宫颈癌普查工作中的应用现状及临床意义。方法2015年5月到2015年10月选择在我院进行宫颈癌普查的新疆兵团库尔勒地区妇女2500例,分别进行TCT普查以及HPV-DNA检测,TCT检查结果为异常以及HPV检测阳性的患者进行阴道镜下宫颈病变组织的活检。结果在2500例妇女中,TCT检测显示异常97例(3.88%);HPV-DNA检测阳性检查率为阳性检查率为121例(4.84%);病变组织活检,阳性检出率为28.16%(58/206),阴性检出率为71.84%(148/206);TCT普查方法的敏感度为89.65%(52/58),特异度为69.59%(103/148);HPV检测的灵敏度为82.76%(48/58),特异度为50.67%(75/148)。结论 TCT和HPV-DNA检测在宫颈癌普查工作中的应用具有很好的价值,在实际临床检测中,将两种方法进行结合是行之有效的方法,从而做到早发现和早治疗。

Objective To investigate the application status and clinical significance of cervical cancer screening in TCT and HPV-DNA in Xinjiang production Korla district. Methods 2500 cases of cervical cancer in our hospital in Korla between May and October in 2015 were selected. First, All cases were taken TCT, and HPV-DNA detection and pathological examination. The patients whose TCT results were abnormal or who had HPV positive results were taken biopsy under colposcopy for cervical lesions. Results Among 2500 cases, the TCT survey showed that 97 cases（3.88%） were abnormal; 121 cases（4.84%） were positive for HPV-DNA, after lesion biopsy, positive rate were 28.16%（58/206）, negative rate were 71.84%（148/206）; sensitive rate of TCT were 89.65%（52/58）,specificity were 69.59%（103/148）, sensitive rate of HPV were 82.76%（48/58）, specificity were 50.67%（75/148）. Conclusion Application of TCT and HPV-DNA has a good value in the diagnosis of cervical cancer, it is the best choice to combine two methods in order to treat earlier.