二仙地黄汤对改善2型糖尿病肾病患者胰岛素抵抗及肾功能代谢指标的作用研究

Erxian Dihuang decoction impact of insulin resistance and metabolic renal function in patients with type 2 diabetic nephropathy

目的:分析2型糖尿病肾病(DN)治疗中二仙地黄汤对胰岛素抵抗及肾功能的影响,为临床治疗提高参考。方法:将80例DN患者作为观察对象,并以随机数字表法将患者随机分为两组,对照组接受常规西药治疗,治疗组在常规西药治疗的基础上联合应用二仙地黄汤,每组40例。对比两组治疗前后血糖控制情况、胰岛素抵抗改善情况及肾功能改善情况。结果:入组时两组间空腹血糖(FPG)、餐后2h血糖(2hBG)、稳态胰岛素评价指数(HOMAIR)、血清脂联素、肌酐(Cr)、尿素氮(BUN)及24h尿蛋白(24hmAlb)比较,差异均未见统计学意义(P>0.05);而在完成4周治疗时,两组间FPG及2hBG比较,差异未见统计学意义(P>0.05);但在完成4周治疗时治疗组HOMA-IR、血清脂联素水平、Cr、BUN及24hmAlb均明显低于对照组,差异存在统计学意义(P<0.05)。结论:二仙地黄汤可显著地改善DN的胰岛素抵抗及肾功能。

Objective：To analyze the Erxian Dihuang decoction impact of insulin resistance and metabolic renal function in patients with type 2diabetic nephropathy.For improve the reference of clinical treatment.Methods：80patients with DN as research object.Application of random number table method,80 patients were randomly divided into two groups.Control group received routine western medicine treatment,treatment group on the basis of conventional treatment of western medicine combined Erxian Dihuang decoction,40 cases in each group.Compared the insulin resistance improved glucose control and improve renal function before and after treatment of the two groups.Results：There was no statistically significant difference of fasting blood glucose（FPG）,postprandial 2hours blood glucose（2HBG）,steady state evaluation index of insulin（HOMA IR）and serum adiponectin,creatinine（Cr）,urea nitrogen（BUN）,and24 hurine protein（24hmAlb）of the two groups before treatment.And after 4weeks treatment,there was no statistically significant difference of FPG and 2HBG comparison between the two groups（P〈0.05）.But after 4weeks treatment the HOMA IR,serum adiponectin levels,Cr,BUN and 24 hmAlb of treatment group were significantly lower than the control group（P〈0.05）.Conclusion：Erxian Dihuang decoction can significantly improve the DN of insulin resistance and the renal function.