摘要
tuftsin是机体脾脏产生的一段生理活性肽,其基本功能是刺激巨噬细胞和粒细胞,提高促吞噬的能力;其对肿瘤细胞并没有直接杀伤效应,但可以通过增强效应细胞的细胞毒功能杀伤肿瘤细胞,在抗感染和抗肿瘤方面具有不可替代的作用。但由于其肽链短、易被水解的特性,至今难以成药而应用于临床。tuftsin的系列衍生物以及与其他药物联用却可提高其抗癌活性,具有广阔的研究前景;尤其是衍生物T肽具有明显的抗肿瘤作用,其作用机制基本明确,可望成为新型抗肿瘤生物反应调节剂。
tuftsin,a physiologically active peptide,can promote phagocytosis,basically stimulates the macrophages or neutrophils and improve their phagocytotic function. tuftsin can not directly kill tumor cells. Due to its short structure and the characteristics of being susceptible to hydrolysis,it is difficult for tuftsin to be made into medicine and applied clinically. However,derivatives of tuftsin-series and combination of tuftsin with other drugs can greatly enhance the cytotoxic effect on tumor cells of tuftsin. It has a broad prospect of research,especially derivative-TP has a significant anti-tumor effect. Its mechanism is clear and its is expected to become a new type of anti-tumor biological response regulator.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2016年第6期747-750,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 30973564)
国家科技部"重大新药创制"科技重大专项综合新药研究开发技术大平台项目(No 2012ZX09301003-001)
