臂旁核神经元调节睡眠觉醒的研究进展

Regulatory effects of PB on sleep and wakefulness

臂旁核(parabrachial nucleus,PB)是环绕在脑桥结合臂周围的灰质结构,主要由谷氨酸、γ-氨基丁酸(γ-aminobutyric acid,GABA)和脑啡肽神经元组成。PB与下丘脑、基底前脑等觉醒核团有着广泛的神经纤维联系,特异性损毁PB可引起动物昏迷样症状。同时,PB向非快动眼(non-rapid eye movement,NREM)睡眠核团腹内侧视前区投射,并接受来自面旁核的投射,激活面旁核中的GABA能神经元可促进NREM睡眠,表明PB可能参与NREM睡眠的调控。此外,快动眼(rapid eye movement,REM)睡眠剥夺会引起臂旁外侧核的兴奋。综上所述,PB在机体调节觉醒、NREM和REM睡眠中发挥着重要作用。该文将就PB在睡眠-觉醒调节作用中的研究进展做一综述。

The parabrachial nucleus( PB) is made up of gray matter around the Pons combination( BC),mainly consisting of glutamatergic,GABAergic and enkephalinergic neurons. PB is connected to hypothalamus and basal forebrain through a network of nerve fibers. Specific lesion of the entire parabrachial complex in animals leads to a deep coma. PB also projects to the nonrapid eye movement( NREM)-related regions including the ventrolateral preoptic,and receives the projections from the parafacial zone. Activation of the GABAergic neurons in parafacial zone can promote NREM sleep,which indicates that PB participates in NREM sleep. Furthermore,the lateral PB is actived when rapid eye movement( REM) sleep is deprived. In conclusion,PB participates in regulating wakefulness, NREM and REM sleep. This review summarizes the advances in the roles of PB in sleep-wake regulation.