摘要
1例67岁男性急性坏疽性阑尾炎患者行急诊阑尾切除术后静脉滴注头孢曲松钠（2g、1次／12h）和奥硝唑（0．5g、1次／12h）。3d后根据术中所取脓液的细菌培养和药物敏感试验结果换用哌拉西林钠他唑巴坦钠（4．5g、1次／8h静脉滴注）。术前患者PLT为288×10^9／L，换药后第2天为308×10^9／L，第12天达1128×10^9／L。骨髓涂片检查显示增生性骨髓象。考虑血小板升高可能与哌拉西林钠他唑巴坦钠相关。停用该药，改用头孢哌酮舒巴坦钠（3g、1次／12h静脉滴注）。停用哌拉西林钠他唑巴坦钠第10天，患者PLT为360×10^9／L；第25天，PIJT为332×10^9／L。
A 67-year-old man with acute gangrenous appendicitis received intravenous infusion of ceftriaxone sodium （2 g once every 12 hours ） and ornidazole （0.5 g once every 12 hours） after emergency appendectomy. Three days later, antibiotics were changed to piperacillin sodium and tazobactam sodium （g. 5 g once every 8 hours by intravenous infusion） based on the results of drug sensitivity. His platelet count （PLT） was 288 × 10^9/L before the operation, 308 × 10^9/L on the second day and 1 128 × 10^9/L on the 12th day of piperacillin sodium and tazobactam sodium treatment. The examination of bone marrow smear showed hyperplasia of bone marrow. Thrombocytosis was considered to be related to piperacillin sodium and tazobactam sodium, piperacillin sodium and tazobactam sodium was withdrawn and cefoperazone sulbactam sodium （3 g once every 12 hours by intravenous infusion） was given. After 9 days of treatment, his platelet count decreased to 360 × 10^9/L. Fifteen days later, his platelet count was 332× 10^9/L.
出处
《药物不良反应杂志》
CSCD
2016年第2期142-143,共2页
Adverse Drug Reactions Journal
