AGEs介导的糖尿病肾损伤机制及二甲双胍的干预作用

Mechanisms of diabetic nephropathy mediated by AGEs and effects of metformin intervention

糖尿病肾病(diabetic nephropathy,DN)是糖尿病(diabetes mellitus,DM)的常见的慢性微血管并发症之一。慢性高糖状态下糖基化终末产物(AGEs)形成增加,诱导肾脏氧化应激和内质网应激,参与糖尿病肾病的发生与发展。二甲双胍是目前临床治疗糖尿病的最常用药物之一。越来越多的研究表明,二甲双胍除了最主要的降糖作用外,其尚可抑制AGEs形成和具有抗氧化作用,深入研究AGEs与DN的关系,有助于进一步了解DN的发病机制并对干预其发生和发展具有重要的指导意义。

Diabetic nephropathy（DN） is one of the common chronic microvascular complications of diabetes mellitus（DM）.Higthexpression of advanced glycation products（AGEs） during high glucose conditions involved in the occurrence and development of diabetic nephropathy by inducing renal oxidative stress and endoplasmic reticulum stress（ERS）.Metformin is one of the drugs used widely for the treatment of type 2 diabetes mellitus.Many evidences demonstrated that metformin not only can control glycemic,but also inhibit the production of AGEs and oxidative stress.Studying the relationship between AGES and diabetic nephropathy can help further understand the pathogenesis of diabetic nephropathy,and make some important guideline for DN treatment.