多巴胺D1、D2受体与觉醒及全身麻醉意识恢复的研究进展

Research advances in the-role of D1, D2 receptor in the awake and promotion of general anesthesia recovery ofconsciousness

背景脑内多巴胺（dopamine，DA）及其受体参与觉醒、运动、认知和奖赏等行为调控，目前研究发现D1、D2受体也参与了全身麻醉意识恢复过程，但其具体机制尚未明确。目的探讨DA参与全身麻醉动物意识恢复的机制及其与D1、D2受体的关系。内容对DAD1和D2受体的结构、信号转导途径及其在中枢神经系统内的分布作一总结，对D1和D2受体参与全身麻醉后意识恢复中的机制研究进展作一综述。趋向D1、D2受体参与了全身麻醉动物意识恢复的过程，为研究和解释全身麻醉意识恢复机制提供新思路。

Background In the brain, dopamine （DA） and its receptors have been implicated in a variety of brain functions, including arousal, motor behavior, cognition and reward. Several recent studies have found that dopamine D1 and D2 receptors are involved in the recovery of consciousness from general anesthesia, but the underlying mechanism for this is still unclear. Objective The aim of this study is to discuss the role of dopamine D1 and D2 receptors in the recovery of consciousness from general anesthesia. Content The present review focuses on the structure, signal transduction pathways and expression of central nervous system dopamine D1 and D2 receptors. We also provide an overview about the latest research progress of D1 and D2 receptors in the recovery of consciousness from general anesthesia. Trend Dopamine D1 and D2 receptors are involved in the recovery process of consciousness from general anesthesia. It may provide a new direction for us to profound understanding the underlying mechanism of general anesthesia-induced unconsciousness.