利那鲁肽联合胰岛素治疗2型糖尿病临床分析

Clinical analysis of liraglutide combined with insulin in the treatment of type 2 diabetes mellitus

目的分析和研究利那鲁肽联合胰岛素治疗2型糖尿病的临床效果。方法 100例2型糖尿病患者,根据随机数字表法分为单用组和联合组,每组50例。单用组患者给予胰岛素治疗,联合组患者给予胰岛素+利那鲁肽治疗。比较两组治疗前后体质量指数(BMI)、空腹血糖(FBG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(Hb A1c)、胰岛素敏感指数、低血糖发生率。结果治疗后两组FBG、2 h PG、Hb A1c、胰岛素敏感指数均有所改善,且联合组改善幅度优于单用组,组间比较差异具有统计学意义(P<0.05);治疗后联合组BMI下降,而单用组则略有升高,组间比较差异具有统计学意义(P<0.05);且联合组低血糖发生率2.0%明显低于单用组10.0%,组间比较差异具有统计学意义(P<0.05)。结论利那鲁肽联合胰岛素治疗2型糖尿病效果确切,可减轻体质量,改善血糖水平和提高胰岛素敏感性,控制低血糖风险的发生,值得推广。

Objective To analyze and research clinical effect by liraglutide combined with insulin in the treatment of type 2 diabetes mellitus. Methods A total of 100 patients with type 2 diabetes mellitus were divided by random number table into single group and combined group, with 50 cases in each group. The single group received insulin for treatment, and the combined group received insulin ＋ liraglutide for treatment. Comparison was made on body mass index（BMI）, fasting blood glucose（FBG）, 2 h postprandial blood glucose（2 h PG）, glycosylated hemoglobin（Hb A1c）, insulin sensitivity index, and incidence of hypoglycemia between the two groups. Results After treatment, both groups had improved FBG, 2 h PG, Hb A1 c and insulin sensitivity index, and the combined group had better improvement than the single group. The difference between the two groups had statistical significance（P〈0.05）. After treatment, the combined group had reduced BMI, while the single group had slightly increased BMI, and their difference had statistical significance（P〈0.05）. The combined group had much lower incidence of hypoglycemia as 2.0% than 10.0% of the single group, and the difference had statistical significance（P〈0.05）. Conclusion Combination of liraglutide and insulin provides precise effect in treating type 2 diabetes mellitus. This method can improve blood glucose level, increase insulin sensitivity and control occurrence of hypoglycemia. It is worth promoting.