中药冠通四号对家兔实验性心肌梗塞后心电图恢复过程及心肌微血管的影响

THE EFFECT OF “GUAN-TONG” NO.4 ON THE RECOVERY PROCESS OF EXPERIMENTAL MYOCARDIAL INFARCTION IN RABBITS,WITH EKG AND MICROVASCULATURE OF HEART MUSCLE AS PARAMETERS

冠通四号是我院第一附属医院用于门诊冠心病人的药物,临床观察为减少心绞痛发作频率及减轻疼痛方面疗效较好的药物之一。为了观察其疗效是否与改善缺血心肌侧支循环的作用有关,本实验在家兔结紥冠状动脉前降支复制慢性实验性心肌梗塞模型,并对该模型进行心电图检查及观察心肌内血管演变的情况,以了解心肌梗塞的自然演变过程,尤其是侧支循环的演变过程及冠通四号对该过程的影响。

"Guan-tong No. 4" injection (a Chinese herbal extract) was given 24 hrs. after ligation of the anterior descending coronary artery in rabbits, with dosage of 6ml/day intravenously for 30 days. Control rabbits received no special treatment. In the treated group the vascular network around the myocardial infarct is more profuse, with larger caliber and appeared much earlier than that in the control group. At the same time there is much more complete recovery in EKG, and less retrograde development in the treated rabbits. The differences between these parameters in the two groups are statistically significant. These results indicated that daily infusion of "Guan-tong No. 4" 24 hrs after the production of myocardial infarction may promote the development of collateral circulation in the myocardium and thus accelerated the recovery process and limited the infart area of the myocardial infartion. It is believed that the effect would be still better if the injection were given right after the coronary ligation and continued for a longer period of time.