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休克发病机制与实验治疗的研究——小肠缺血在休克发病学中的作用 被引量:8

RESEARCH ON PATHOGENETIC MECHANISM AND EXPERIMENTAL THERAPY OF SHOCK——EFFECT OF INTESTINAL ISCHEMIA ON THE PATHOGENESIS OF SHOCK
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摘要 休克过程的一个重要特点是:当它发展到一定阶段后,尽管针对病因和发病环节进行了积极治疗,过程仍循恶性循环进行性地加重以至死亡。关于休克的这种不可逆机制目前还不清楚,许多学者注意到休克时缺血的腹腔内脏对休克不可逆发展有特别重要的意义。我们利用肠系膜上动脉闭塞性休克(Superior mesenteric artery occlusion shock,简称SMAO休克)模型,以H2O2,654-2,POB作实验性治疗,对小肠缺血在休克发病学中的作用进行探讨并分析了654-2抗休克的机理,结果报告如下。 Superior mesenteric artery occlusion (SMAO)shock was reproduced in rabbits under local anesthesia as shock model. It Was shown that primary intestinal ischemic damage itself could lead to severe irreversible shock. Further experiments demonstrated that antegrade intraarterial infusion of H_2O_2 IE, or Ⅳ medication of Anisodamine had improved intestinal tissue ischemia, and prevented the irreversibility of the shock process. These results suggested that small intestine is probably the "key organ" in the occurrence of irreversible shock.654-2 given intraenterically decreased the release of lysozymal enzyme (acid phosphatase) from the ischemic intestine, which tissue was obviously protected, and shock could be relieved, while α-adrenergic blocking agent phenoxybenzamine showed no antishock effect in our experimens
出处 《北京大学学报(医学版)》 CAS 1981年第4期277-281,共5页 Journal of Peking University:Health Sciences
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同被引文献13

  • 1韩敏,李俊杰,张静,牛春雨,姜华,赵自刚,刘彦凯,张学锋.正常淋巴液对大鼠急性微循环障碍的干预作用[J].中国急救医学,2004,24(9):656-658. 被引量:7
  • 2杨亦青,樊贵,韩敏,姜华,赵自刚,刘艳凯,牛春雨,张静.淋巴液对内毒素休克大鼠的干预作用及其机制[J].中国急救医学,2004,24(9):661-664. 被引量:16
  • 3牛春雨,张静,樊贵,穆铮.淋巴液对失血性休克大鼠肠系膜微循环变化的影响[J].微循环学杂志,1996,6(3):1-3. 被引量:15
  • 4Niu CY,Zhang J,Fan G.The antagonistic effect of lymph on shock in rat[J].Lymphology,2002,31(Suppl):159-162.
  • 5Bollman JL,Cain JC,Gaindlay JII.Tichnique for the collection of lymph from the liver,small intestine,or thoracic duct of the rat[J].J Lab Clin Med,1948,33:1349-1351.
  • 6戴龙君,丁鼎武.自由基与心肌缺血性损伤[J]生理科学进展,1987(02).
  • 7Jing-yi Su,Carl E. Hock,Allan M. Lefer. Beneficial effect of anisodamine in hemorrhagic shock[J] 1984,Naunyn - Schmiedeberg’s Archives of Pharmacology(4):360~365
  • 8苏静怡.山莨菪碱(654-2)抗体休克作用机制的研究进展[J]生理科学进展,1985(04).
  • 9朱宇,苏静怡.山莨菪碱对失血性休克大鼠肝脏溶酶体的保护作用[J]北京医学院学报,1985(03).
  • 10唐朝枢,杨晓红,王宪,赵起,苏静怡.山莨菪碱(654-2)的钙拮抗作用[J]北京医学院学报,1985(03).

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