易卒中型肾血管性高血压大鼠模型

Establishment of the model of stroke-prone renovascular hypertensive rats.

用内径为0.30mm的银夹钳夹双侧肾动脉,复制出一种易卒中型肾血管性高血压大鼠模型,其血压峰值高且稳定在26.7kPa以上,并发生与人类高血压病类似的脑动脉损害:细小动脉纤维素样坏死、透明变性和微动脉瘤形成等,在此基础上,0.56的大鼠自发产生各种类型的脑卒中:脑梗塞、脑出血、蛛网膜下腔出血和混合性脑卒中。本文还着重将这种易卒中型肾血管性高血压大鼠与易卒中型自发性高血压大鼠作了比较。

After the renal arteries were constricted bilaterally with silver clips,0.30 mm in internal diameter,the renovascu-lar hypertension was produced in all 55 operated Sprague-Dawley rats.The blood pressure values in the renovascular hypertensive rats (RHR) were higher and remained over 26.7 kPa.Febrinoid necrosis,hyalinosis and formation of micr-oaneurysm,that closely resmble the cer-erovascular lesions in human hypertension,were obsereved in the arterioles or small arteries.The attack rate of spontaneous stroke was 0.564(31/55) when the RHRS were fed with a standard rat.chow diet (0.23 protein,0.047 fat and 0.0024 salt).The type of stroke included cerebral haemorrhage,cerebral infarction,subarachnoid haemorrhage and mixed stroke.To be compared with the excellent animal model of stroke at present——the stroke-prone spontaneouslyhypertensive rats (SHRSP),the RHR are free from genetic deficiency,easy to be raised and can be supplied for studies in a large number,therefore the stroke-prone renovascular hypertensive rats (RHRSP) are more useful in the studiesof hypertension and its complications.