龙葵承气汤对原发性肝癌患者TACE术后肝纤维化指标及免疫功能的影响

Clinical Observations of Longkui Chengqi tang on Liver Fibrosis Indexes and Immunologic Function of Patients with Primary Liver Cancer after TACE

目的:观察龙葵承气汤对原发性肝癌肝动脉栓塞化疗(TACE)术后患者肝纤维化指标及免疫功能的影响。方法:将入院病例分为治疗组22例和对照组18例。治疗组予常规TACE、护肝治疗加龙葵承气汤,对照组以常规TACE与护肝治疗。2组均以4周为1疗程,观察3疗程。观察2组治疗前后的肝纤维化指标、T淋巴细胞亚群及自然杀伤(NK)细胞的变化。结果:治疗后,治疗组透明质酸(HA)较治疗前下降,差异有统计学意义(P<0.05);肝胆酸(CG)、三型前胶原肽(PC3)、层黏蛋白(LN)较治疗前升高不明显或略下降,差异均无统计学意义(P>0.05)。对照组CG、HA、PC3、LN较治疗前均有升高,差异均有统计学意义(P<0.05)。对照组CG、HA、PC3、LN值均高于治疗组,差异均有统计学意义(P<0.05)。治疗后,治疗组NK细胞、CD4^+/CD8^+均较治疗前增高,差异均有统计学意义(P<0.05);而对照组NK细胞治疗前后变化不大,CD4^+/CD8^+则较治疗前下降,但差异无统计学意义(P>0.05)。治疗组NK细胞、CD4+/CD8+与对照组比较,差异均有统计学意义(P<0.05)。结论:在TACE基础上联合使用龙葵承气汤治疗原发性肝癌患者,可起到抗肝纤维化、提高患者细胞免疫功能的作用,可能对延长患者的远期生存有一定意义。

Objective：To observe the effect of Longkui Chengqi tang on hepatic fibrosis indexes and immunologic function of patients with primary liver cancer after transcatheter hepatic arterial chemoembolization（TACE）. Methods： The patients were divided into 2 groups,22 cases in the treatment group and 18 cases in the control group. The patients in the treatment group were treated with conventional TACE,liver-protecting therapy added by Longkui Chengqi tang;the patients in the control group were treated with conventional TACE and liver-protecting therapy. Regarding 4 weeks as one treatment course in 2 groups,observed results after 3 treatment courses. Observe the changes of liver fibrosis indexes,T achroacyte subgroup and NK cells of 2 groups after treatment. Results：After treatment,hyaluronic acid（HA） in the treatment group was decreased,as comparing with that before treatment, differences being significant（P〈0.05）; serum chileglycine（CG）, Type ⅲ Procollagen Peptide（PC3） and laminin（LN） were improved slightly（P〈0.05）. The levels of CG,HA,PC3 and LN in the control group were all increased,as comparing with those before treatment,differences being significant（P〈0.05）. The levels of CG,HA,PC3 and LN in the control group were all higher than those in the treatment group（P〈0.05）. After treatment,the levels of NK cells and CD4~＋/CD8~＋ in the treatment group were all higher than those before treatment（P〈0.05）;while the levels of NK cells and CD4~＋/CD8~＋ in the control group were changed slightly（P〈0.05）. Comparing the levels of NK cells and CD4~＋/CD8~＋ between the two groups,difference was significant（P〈0.05）. Conclusion：The application of Longkui Chengqi tang on treating patients with primary liver cancer on the basis of TACE can play an important role of anti-liver fibrosis and improving cells immunologic function of patients, which is significant on extending long-dated survival of patients.