2294例生殖异常者的染色体核型分析

Analysis of chromosome karyotype of 2294 cases with reproduction abnormalities

目的:探讨生殖异常者与染色体核型异常的关系。方法:对2 294例生殖异常者的外周血进行培养并行常规G显带、核型分析。结果:2 294例生殖异常者中检出221例染色体核型异常,核型异常率为9.63%,其中常染色体结构异常33例,性染色体数目异常26例,性染色体结构或功能异常6例,染色体多态性核型156例。结论:染色体核型异常是导致生殖异常的重要原因。

Objective： To discuss the relationship between reproduction abnormality and chromosome karyotype. Methods： Chromosome karyotypes and clinical data of 2 294 patients with reproduction abnormalities during the last four years were analyzed. Results： In 2 294 patients with reproduction abnormality, 221 cases were of abnormal chromosome karyotype, the abnormal chromosome karyotype rate was 9.63%. Among 221 cases, 33 cases were of abnormal euchromosome structure, 26 cases were of abnormal sex chromosome number, 6 cases were of abnormal sex chromosome structure or function, and 156 cases were of chromosome polymorphism karyotype. Conclusion： Chromosome karyotype abnormity is one of the important factors in patients with reproduction abnormality. It is necessary for patients with reproduction abnormality to take chromosome karyotype examination.