普米克和特布他林雾化吸入治疗小儿毛细支气管炎的临床随机对照研究

目的探讨普米克联合特布他林雾化吸入治疗小儿毛细支气管炎的临床疗效和安全性。方法选取208例毛细支气管炎患儿为研究对象,采用随机数字表法将所选患儿分为研究组和对照组,各104例。对照组静脉应用地塞米松、硫酸镁注射液治疗,同时口服硫酸沙丁胺醇,研究组使用普米克联合特布他林雾化吸入治疗。比较2组患儿治疗总有效率、临床症状消失时间及不良反应发生率的差异。结果研究组治疗总有效率为97.1%,高于对照组的85.6%(P<0.05);研究组患儿咳嗽、肺部湿啰音、喘息、心率异常等症状恢复时间均较对照组快(P<0.05);研究组患儿不良反应发生率低于对照组(P<0.05)。结论高压泵雾化吸入普米克及特布他林治疗小儿毛细支气管炎临床效果好,依从性强,安全性高,不良反应小,值得推广。

Objective To investigate the effects and safety of pulmicort combined with terbutaline inhalation therapy for the treatment ofchildren with capillary bronchitis. Methods 208 cases of children with capillary bronchitis in our hospital were randomly divided into research groupand control group, each were 104 cases. The control group were treated with dexamethasone, magnesium sulfate injection therapy and albuterolsulfate oral. The research group were treated with pulmicort combined with terbutaline inhalation therapy. The total effective rate, clinical symptomsdisappeared time and adverse reactions rate of two groups were compared. Results The total effective rate of research group was 97. 1%, which washigher than 85. 6% of control group （P〈0. 05）. The cough, crackles, wheezing, heart abnormalities and other symptoms recovery time of researchgroup were shorter than control group （P〈0. 05）. The complications rate of research group was lower than control group （P〈0. 05）. ConclusionPulmicort combined with terbutaline high-pressure pump inhalation for children with capillary bronchitis is effective and safe. It’s worthy of clinicalwidely used.