布地奈德喷鼻剂联合悬雍垂腭咽成形术治疗阻塞性睡眠呼吸暂停低通气综合征的效果评价

The Effect Evaluation of Budesonide Nasal Spray Combined with Uvulopalatopharyngoplasty for Treatment of Obstructive Sleep Apnea Hypopnea Syndrome

目的评价布地奈德鼻喷剂联合悬雍垂腭咽成形术治疗阻塞性睡眠呼吸暂停低通气综合征（OSAHS） 患者的客观效果.方法：将60 例成年OSAHS 患者,术前进行多导睡眠监测（PSG） 后,随机分为两组,对照组30 例单纯行悬雍垂腭咽成形术,试验组30 例行布地奈德鼻喷剂联合悬雍垂腭咽成形术,术后3-6 个月后再次行PSG,比较两组的治疗效果.结果：术后3-6 个月复查PSG,对照组治愈2 例（6.7%）,显效14 例（46.7%）,有效6 例（20.0%）,无效8 例（26.7%）,总有效22 例（73.3%）;试验组治愈5 例（16.7%）,显效18 例（60.0%）,有效6 例（20.0%）,无效1 例（3.3%）,总有效29 例（96.7%）;试验组总有效率高于对照组,差异有统计学意义（ 字2=4.706,P=0.030）.结论：对OSAHS 患者使用布地奈德鼻喷剂联合悬雍垂腭咽成形术疗效大于单纯腭咽成形术.

Objective:To evaluate the effect of Budesonide nasal spray combined with uvulopalatopharyngoplasty for treatment of patients with obstructive sleep apnea hypopnea syndrome.Method:60 adult patients with OSAHS were randomly divided into two groups after the operation of multiple conduction sleep monitoring(PSG),the control group of 30 cases were treated with uvulopalatopharyngoplasty,30 cases of the experimental group were used Budesonide nasal spray combined with uvulopalatopharyngoplasty,the treatment effect of the two groups was compared.Result:After 3-6 months follow-up PSG,control group,2 cases(6.7%) were cured,markedly effective in 14 cases(46.7%),effective in 6 cases(20.0%), ineffective in 8 cases(26.7%),the total effective in 22 cases(73.3%);experimental group cure in 5 cases(16.7%),markedly effective in 18 cases(60.0%),effective in 6 cases(20.0%),invalid in 1 case(3.3%),the total effective in 29 cases(96.7%);the experimental group total efficiency was higher than that of the control group,the difference was statistically significant(χ2=4.706,P=0.030). Conclusion:The use of OSAHS in patients with Budesonide nasal spray combined with uvulopalatopharyngoplasty effect than simple palatopharyngoplasty.