桃红四物颗粒的初步药效学研究

Pharmacodynamic evaluation of Taohong Siwu Granules

目的对复方桃红四物汤颗粒(TSG)的药效学作出初步评价并比较传统水煎液桃红四物汤(TSD)作用的差异。方法通过复制急性血瘀证大鼠模型,治疗组通过给予不同剂量的桃红四物颗粒和一定剂量的阳性对照药,观察模型建立的情况,检测相关血液流变学和生化指标,探究桃红四物颗粒的初步药效学情况。结果桃红四物颗粒能够降低模型大鼠的全血黏度和血浆黏度,有效改善其血流变的功能;有效降低模型大鼠血清中内皮素-1(ET-1)的水平,升高一氧化氮(NO)的水平。结论根据试验结果,桃红四物颗粒能够有效改善急性血瘀模型大鼠的血液流变功能,可能通过降低大鼠血清中ET-1、升高NO而发挥作用。

Objective To evaluate the pharmacodynamic effect of Taohong Siwu Granules and compare its difference from the traditional Taohongsiwu Decoction. Methods By copying the acute blood stasis model rats,the treatment group was given different doses of Taohong Siwu granule and a certain dose of positive control drug. Observation model was established,and the related blood rheology and biochemical indicators were detected to explore the primary pharmacodynamics effect of Taohong Siwu granule. Results Taohong Siwu granule could decrease the whole blood viscosity and plasma viscosity of model rats,improve the function of the level of blood rheology,effectively reduced the model rats' serum endothelin-1( ET-1) levels,and elevated the levels of nitric oxide( NO). Conclusions According to the test results,Taohong Siwu granule can effectively improve the function of hemorrheology in acute blood stasis model rats,and may play the role by reducing the rat serum ET-1 and increasing nitric oxide.