尿素氮、肌酐、尿酸联合检测在妊娠期高血压疾病肾损害评估中的应用

Application of urea nitrogen,creatinine,uric acid combined detection in kidney damage assessment of pregnancy-induced hypertension

目的探讨尿素氮、肌酐、尿酸联合检测在妊娠期高血压疾病肾损害评估中的应用。方法采用日立7180全自动生化分析仪测定妊娠期高血压疾病患者132例[按24h尿白蛋白排泄率（UAER）分为轻度46例、中度41例、重度45例]血清尿素氮、肌酐、尿酸水平。结果妊娠期高血压疾病组尿素氮、肌酐、尿酸水平明显高于对照组（P〈0．05）。妊娠期高血压疾病肾损害重度组血清尿素氮、肌酐、尿酸水平明显高于中度组和轻度组，而中度组血清尿素氮、肌酐、尿酸水平明显高于轻度组（P〈0．05）。尿素氮、肌酐、尿酸为诊断指标的ROC曲线下面积为0．754（95％C10．722～0．798）、0．801（95％C10．715～0．869）和0．826（95％C10．728～0．881）。结论血清尿素氮、肌酐、尿酸水平在妊娠期高血压疾病患者中明显升高，并且随肾损害加重呈进行性升高，对妊娠期高血压疾病患者中重度肾损害具有较高的诊断价值。

Objective To explore the application of urea nitrogen,creatinine,uric acid combined detection in kidney damage assessment of pregnancy-induced hypertension. Methods Serum urea nitrogen,creatinine,uric acid were detected by Olympus AU 1000 automatic biochemical analyzer in 132 cases of pregnancy-induced hypertension [assigned into mild with 46 cases,moderate 41 cases,severe 45 cases according to 24 h urinary albumin excretion rate( UAER) ]. Results Serum urea nitrogen,creatinine,uric acid in pregnancy-induced hypertension group were significantly higher than those in control group( P < 0. 05). Serum urea nitrogen,creatinine,uric acid in severe pregnancy-induced hypertension group were significantly higher than those in mild and moderate group( P <0. 05),and those in moderate group were significantly higher than those in mild group( P < 0. 05). The areas under ROC curve of serum urea nitrogen,creatinine,uric acid were 0. 754( 95% CI 0. 722 ~ 0. 798),0. 801( 95% CI 0. 715 ~ 0. 869) and 0. 826( 95% CI 0. 728 ~0. 881),respectively. Conclusions Serum urea nitrogen,creatinine,uric acid are significantly increased in pregnancy-induced hypertension,and gradually increased with aggravation of kidney damage,which has high diagnostic value in assessment for moderate and severe kidney damage of pregnancy-induced hypertension.