抑炎性细胞因子在多发性硬化中的研究进展

Advances of anti-inflammatory cytokines in multiple sclerosis

多发性硬化是最常见的中枢神经系统炎性脱髓鞘性疾病,目前其病因及发病机制尚不明确,治疗手段也有限。抑炎性细胞因子通过参与免疫耐受性的产生,降低多发性硬化患者体内的炎性反应。合理地理解抑炎性细胞因子在多发性硬化中的免疫调节机制,将对多发性硬化发病机制及相关药物治疗的研究有重要价值。

Multiple sclerosis is the most common inflammatory demyelinating disease of the central nervous system. At present, its etiology and pathogenesis are unclear, and its treatment is also limited. Anti-inflammatory cytokines are involved in the generation of immunotolerance, and can protect the host during immune responses. Rational understanding of the immunoregulatory mecha-nisms will have a considerable effect on pathogenesis and drug therapy for multiple sclerosis.