血小板参数与绝经后骨质疏松症相关性的初步研究

Preliminary study on the relationship between platelet parameters and osteoporosis in postmenopausal women

目的探讨血小板参数(PLT、MVP、PDW、PCT)与绝经后骨质疏松之间的相关性。方法2013年5月至2015年6月间,回顾性分析126例重庆常住汉族绝经后妇女,根据双能X线骨密度仪测定髋关节(股骨颈、大转子、转子间、全髋区和Ward’s区)、腰椎骨密度的结果,分为骨质疏松组65例,骨量减少组33例及骨量正常组28例,同时检测所有患者的血小板参数包括,PLT、MVP、PDW、PCT的水平。应用SPSS 22.0分别对3组的数据进行Pearson相关分析、偏相关系数分析和线性回归分析。结果(1)PLT、MPV、PDW和髋关节、腰椎骨密度三组比较差异显著。(2)Pearson相关分析显示PLT与髋关节、腰椎骨密度呈负相关(P<0.05;P<0.01),MPV、PDW与髋关节、腰椎骨密度呈正相关(P<0.05;P<0.01)。校正年龄、BMI和绝经年限,偏相关系数分析显示MPV、PDW和腰椎骨密度呈正相关(r=0.228,P<0.05;r=0.196,P<0.05)。(3)线性多元逐步回归分析显示PLT与髋关节骨密度存在负相关(P<0.05),MPV、PDW与髋关节、腰椎骨密度存在正相关(P<0.05)。结论血小板参数可能与绝经后骨质代谢紊乱存在相关性。

Objective To investigate the relationship between platelet parameters, PLT,MVP, PDW, and PCT, and osteoporosis in postmenopausal women. Methods A retrospective study was conducted in 126 postmenopausal Han women in Chongqing from May 2013 to June 2015. According to the results of bone mineral density（ BMD）,they were divided to osteoporosis group（ n = 65）,osteopenia group（ n = 33）,and normal bone mass group（ n = 28）. BMD of the hip and lumbar vertebrae was detected using dual energy X-ray absorptiometry. The blood levels of platelet parameters were examined and compared among the three groups using a SPSS 22. 0 software. Results（ 1） There were statistical differences among the 3 groups in the values of PLT,MPV,PDW,and BMD of the hip and lumbar vertebrae.（ 2） Pearson correlation analysis showed that PLT was negatively correlated with BMD of the hip and lumbar vertebrae（ P〈0. 05）. MPV and PDW were positively correlated with BMD of the hip and lumbar vertebrae（ P〈0. 05）. Partial correlation analysis suggested that after controlling the influence of age,postmenopausal years,and BMI,MPV and PDW were positively correlated with BMD of the lumbar vertebrae（ P〈0. 05）.（ 3）Multiple stepwise regression analysis showed that PLT was negatively correlated with BMD of the hip（ P〈0. 05）. MPV and PDW were positively correlated with BMD of the hip and lumbar vertebrae（ P〈0. 05）. Conclusion Platelet parameters may be related to the metabolic disturbance of postmenopausal osteoporosis.