氯丙嗪提高皮瓣存活的实验研究

Experimental Study on Chlorpromazine in Improving Survival Area of Pedicled Skin Flap in Rat

本实验采用随机、双盲、对照研究的方法观察到:氯丙嗪能够明显提高鼠背部皮瓣的存活。同时,本实验提示其机理可能是由于氯丙嗪降低了皮瓣的代谢,从而提高了皮瓣对缺血的耐受所致。

In this experiment, an observation was obtained by randomized, double blind, and controlled method. From the measurment of the flap survival area and the histological examination it was suggested that chlorpromazhne could markedly increase the survival area of the pedieled flap on the back of the rat. The measurment of the glucose and lactic acid content suggested that the mechanism was due to the decreased metabolism of the flap by ehlorpromazine, which might improve the endurance of the flap to isehemia.