土大黄根提取物对小鼠非特异性免疫功能的影响

Effects of Rumex L. Root Extract on Non- Specific Immune Function of Mice

目的探讨土大黄根提取物对正常小鼠非特异性免疫功能的影响。方法采用小鼠体内吞噬廓清能力测定试验(惰性炭粒吞噬廓清法),观测土大黄根提取物(1,2,4 g/kg)灌胃给药后,小鼠的一般状况、体重、脾脏及胸腺指数、廓清指数。结果土大黄提取物(1,2,4 g/kg)在试验期间小鼠的一般状况、体重、脾脏及胸腺指数变化无明显异常(P>0.05);各给药组虽能升高正常小鼠廓清指数,但其差异无统计学意义(P>0.05)。结论土大黄根提取物对正常小鼠非特异性免疫功能(单核-巨噬细胞系统吞噬功能)有一定影响。

Objective To explore the effect of Rumex L. root extract on non- specific immune function of mice. Methods Carbon clearance test was used in mice（ inert carbon granule clearance method） to observe the effect of Rumex L. extract administration（ 1,2,4 g / kg） on mice in the general status,body weight,spleen and thymus index and then clearance index. Results There were no obvious abnormality in mice of Rumex L. root extract（ 1,2,4 g / kg） in the general status,body weight,spleen and thymus index（ P〈0. 05）;though the clearance index was increased in normal mice,there was no significant changes（ P〈0. 05）. Conclusion Rumex L. root extract has a certain influence on non- specific immune function（ phagocytosis of mononuclear scavenger system） of mice.