阿奇霉素对支原体肺炎患儿心肌损伤的影响

Effect of Azithromycin on Myocardial Injury in Children with Mycoplasma Pneumonia

目的探讨阿奇霉素对支原体肺炎患儿心肌损伤的影响。方法选取医院2010年2月至2015年2月收治的支原体肺炎患儿80例,按随机数字表法分为治疗组和对照组,各40例。对照组患儿给予常规退烧药和止咳药对症治疗,治疗组患儿在对照组治疗基础上给予阿奇霉素治疗。观察两组患儿心肌酶谱、肌钙蛋白I(cTnI)、肌红蛋白(MB)、糖原磷酸化酶同工酶(GPBB)等指标的变化。结果治疗后,治疗组患儿的天门冬酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、α-羟丁酸脱氢酶(α-HBDH)和肌酸激酶同工酶(CK-MB)水平分别为(20.42±11.45)U/L,(123.35±83.71)U/L),(120.42±53.45)U/L,(90.49±48.32)U/L和(10.29±4.92)U/L,对照组患儿的分别为(58.52±21.19)U/L,(493.45±93.82)U/L,(500.12±143.45)U/L,(319.49±118.42)U/L和(27.16±11.92)U/L,治疗组患儿的各项指标均明显低于对照组患儿(P<0.05);治疗组患儿的cTnI水平为(0.12±0.06)μg/L,明显低于对照组的(0.29±0.10)μg/L(P<0.05);治疗组患儿的MB水平为(40.10±19.24)μg/L,明显低于对照组患儿的(156.91±71.23)μg/L(P<0.05);治疗组患儿的GPBB水平为(3.75±1.02)μg/L,明显低于对照组患儿的(6.75±2.13)μg/L(P<0.05)。结论支原体肺炎患儿通常有心肌损害并发症,阿奇霉素在有效治疗支原体肺炎的同时,还能较好地减轻甚至治疗并发的心肌损伤。

Objective To inuestigate the influence of azithromycin on myocardial injury in children with mycoplasma pneumonia. Methods80 cases of mycoplasma pneumonia children from February 2010 to February 2015 were randomly selected and divided into the treatment group and the control group according to the random number table method,40 cases in each group. The control group was given usual antipyretics and cough medicines and other conventional symptomatic treatment,and on this basis,the treatment group was treated with azithromycin therapy. The changes in the myocardial enzymes,cardiac troponin I（ cTnI）,myoglobin（ MB）,different glycogen phosphorylase isoenzyme（ GPBB） of the two groups were observed. Results After treatment,the AST,LDH,CK,a- HBDH and CK- MB of the treatment group were（ 20. 42 ± 11. 45） U / L,（ 123. 35 ± 83. 71） U / L,（ 120. 42 ± 53. 45） U / L,（ 90. 49 ± 48. 32） U / L and（ 10. 29 ± 4. 92） U / L,which were significantly lower than（ 58. 52 ± 21. 19） U / L,（ 493. 45 ± 93. 82） U / L,（ 500. 12 ± 143. 45） U / L,（ 319. 49 ± 118. 42） U / L and（ 27. 16 ± 11. 92） U / L in the control group（ P〈0. 05）; the level of cTnI in the treatment group was（ 0. 12 ± 0. 06） μg / L,which was obviously lower than（ 0. 29 ± 0. 10） μg / L in the control group（ P〈0. 05）; the level of MB in the treatment group was（ 40. 10 ±19. 24） μg / L,which was obviously lower than（ 156. 91 ± 71. 23） μg / L in the control group（ P〈0. 05）; the level of GPBB in the treatment group was（ 3. 75 ± 1. 02） μg / L,which was obviously lower than（ 6. 75 ± 2. 13） μg / L in the control group（ P〈0. 05）. Conclusion Mycoplasma pneumonia children usually have complications of myocardial damage,azithromycin can effectively reduce or even cure concurrent myocardial injury in the treatment of mycoplasma pneumonia.