癌症基因治疗技术进展与展望

Progress and Prospect of Cancer Gene Therapy

癌症是严重危害人类健康的重大疾病之一,寻找高效可行的癌症治疗方法一直是医学研究的重要课题。继外科手术、放疗、化疗、免疫治疗之后,随着人们对基因组学的深入了解及分子生物学技术的不断发展,基因治疗作为一种全新的治疗理念已被证明具有显著临床疗效及优势。对癌症基因治疗的原理及几种新技术的应用进行介绍,并对基因治疗未来在临床上的应用加以展望。

Cancer is becoming one of the major diseases with serious hazards to human health. To find efficient treatment protocols has always been the important subject in cancer studies. While surgical management,radiotherapy,chemotherapy and immunotherapy have achieved certain effects,there are distinct limits in each method. With the development of data mining methods and molecular experimental technologies,more and more cancer related targets and signaling pathways were discovered from human genome. Based on such knowledge,gene therapy has been proved to be with significant efficacy and superiorities in both experimental and clinical trials. The principle of gene therapy and some recent technologies in cancer gene therapy were summarized. Then the prospects of cancer gene therapy in future clinical application were discussed.