慢加急性肝衰竭的研究进展

Search progress of acute-on-chronic liver failure

慢加急性肝衰竭(ACLF)是一种复杂的临床综合征,病情进展快,病死率极高。早期诊断和治疗可阻断部分患者的病情进展,甚至逆转病情,在一定程度上降低死亡率,改善预后。国内外学者对该疾病广泛关注,并制订了一系列的预后评估系统,但因不同区域ACLF的病因不同,且病理机制复杂,目前,东西方对其定义及诊断标准尚不统一,且缺乏有效的预后评估体系。本文将对ACLF的定义、东西方诊断标准、预后评估体系等进行分析总结。

Acute-on-chronic liver failure refers to a complex clinical syndrome with a fast progress and high mortality.Early diagnosis and intervention may partially block or even reverse the progress of the disease, therefore reduce the mortality and improve the prognosis. Scholars worldwide paid a wide attention to this disease, and formulated a series of prognostic evaluation system. There is discrepancy between the east and the west in the definition and diagnostic criteria for ACLF, and no prognostic evaluation system is currently applicable, because of the different causes and the complexity of pathogenesis. This paper aimed to make a summary of ACLF including the definition, diagnostic criteria of the East and the West, and the prognostic evaluation system.