肺间质纤维化合并肺气肿综合征的临床特点分析

Clinical feature analysis of combined pulmonary fibrosis and emphysema syndrome

目的比较肺间质纤维化合并肺气肿综合征（CPFE）与慢性阻塞性肺疾病（COPD）及特发性肺间质纤维化（IPF）的临床特点。方法 选择2013年1月-2015年6月在我院治疗的CPFE患者34例、IPF患者78例、COPD患者41例的临床资料进行回顾性分析。结果 CPFE患者平均年龄最高,IPF患者平均年龄最低（P〈0.05）;CPFE及COPD患者主要以男性为主（P〈0.05）;CPFE患者肺动脉高压的发生率最高,COPD患者最低（P〈0.05）。CPFE患者肺癌发生率最高,其次为IPF,差异有统计学意义（P〈0.05）。与COPD患者比较,CPFE患者FEV1/FVC%、PA-a O2、FEV1%Pre水平更高,DLCO水平更低,差异有统计学意义（P〈0.01）。与IPF比较,CPFE患者FEV1/FVC%、肺纤维化积分更低,TLC%Pre、PA-a O2水平更高,差异有统计学意义（P〈0.01）。结论 CPFE患者平均年龄较高,以男性为主,肺动脉高压及肺癌发生率高,其肺容积可轻度下降或相对正常,但弥散能力显著下降。

Objective To compare the clinical feature among CPFE,COPD and IPF. Methods Clinical data of 34 CPFE patients,78 IPF patients and 41 COPD patients from January 2013 to July 2015 of our hospital were retrospectively an- alyzed. Results The average age of CPFE patients was the highest and the COPD was the lowest（P〈0.05）.The lung can- cer incidence rate of CPFE patients was highest and followed with IPF,and the difference was statistical significance（P〈 0.05）.Compared with COPD patients,FEVl/FVC%,PA-aO2 and FEVl%Pre level of CPFE patients were the highest,DL- CO level was the lowest,and the difference was statistical significance（P〈0.01）.Compared with IPF patients,FEV1/FVC% and pulmonary fibrosis integral of CPFE patients were lower,TLC%Pre and PA-aO2 level were higher,and the difference was statistical significance（P〈0.01）. Conclusion The average age of CPFE patients are higher and are mainly with man, the incidence rate of pulmonary hypertension and lung cancer are higher,the lung volume can be mild decreased or rel- atively normal,but the dispersion ability decreases obviously.