依达拉奉联合醒脑静治疗高血压性脑出血的临床效果

Clinical effect of Edaravone and Xingnaojing Injection in treating hypertensive cerebral hemorrhage

目的 探讨依达拉奉与醒脑静注射液联合应用治疗高血压性脑出血的临床效果。方法 选择2014年6月-2015年6月期间本院内科收治的48例高血压性脑出血患者,随机将其分为观察组和对照组,每组各24例。对照组给予常规高血压性脑出血治疗,包括应用抗菌药物预防感染、脱水,降低颅内压,控制并发症,维持水电解质平衡以及对症支持疗法。观察组在此基础上,给予依达拉奉注射剂30 mg加入5%葡萄糖或0.9%氯化钠注射液100 ml中静滴,2次/d,14 d为1个疗程,醒脑静注射液20 ml加入5%葡萄糖或0.9%氯化钠注射液250 ml中静滴,1次/d,14 d为1个疗程。结果 对照组基本治愈8例,好转4例,显著进步4例,进步5例,差5例,治疗总有效率为61.54%;观察组基本治愈13例,好转7例,显著进步4例,进步2例,差0例,治疗总有效率为92.31%,观察组治疗总有效率明显高于对照组,差异有统计学意义（P〈0.05）。对照组出现肺部感染2例,泌尿系感染1例;观察组出现肺部感染l例。结论 依达拉奉与醒脑静注射液联合应用治疗高血压性脑出血患者可发挥明显的抗炎作用,可有效改善患者脑功能,提高其生存质量,有较好的疗效及安全性。

Objective To explore the clinical effect of Edaravone and Xingnaojing Injection in treating hypertensive cerebral hemorrhage. Methods 48 hypertensive cerebral hemorrhage patients from June 2014 to June 2015 in our hos- pital were collected and randomly divided into observation group and control group,and each group was 24 cases.Pa- tients in control group were given routine treatment for hypertensive cerebral hemorrhage,antibiotics were used to pre- vent infection,dehydration was used to decrease intracranial pressure and control complications,water and electrolyte balance was maintained and other symptomatic support therapy.On the basis of that,patients in observation group were further given Edaravone Injection 30 mg in 5% glucose or 0.9% sodium chloride injection 100 ml for injection,twice a day for 14 days as an course,and Xingnaojing Injection 20 ml in 5% glucose or 0.9% sodium chloride injection 250 ml for injection,once a day for 14 days as an course. Results The number of basic cure,improve,significant progress, progress,bad and the total effective rate in control group was respectively 8,4,4,5,5 cases and 61.54%,which were re- spectively 13,7,4,2,0 cases and 92.31%,the total effective rate in observation group was obvious higher than that in control group and the difference was statistical significance （P〈0.05）.There were 2 cases with lung infection and 1 with urinary infection in control group;only 1 with lung infection in observation group. Conclusion Edaravone combined with Xingnaojing Injection in treating hypertensive cerebral hemorrhage has obvious anti-inflammation role,which can im- prove the brain function and enhance the life quality,with better effects and safety.