前列腺突入膀胱程度对前列腺增生患者应用α-受体阻滞剂治疗的影响

Influence of intravesical prostatic protrusion on application of α-blocker treated for patients with benign prostatic hyperplasia

目的 探讨前列腺突入膀胱程度（IPP）对前列腺增生（BPH）患者应用α-受体阻滞剂治疗的影响。方法 回顾性分析2012年10月-2015年10月接受α-受体阻滞剂治疗的168例前列腺突入膀胱的前列腺增生症患者的临床资料,并根据IPP程度将患者分为IPP显著组（IPP〉5 mm）63例,IPP非显著组（IPP≤5 mm）105例,研究比较两组BPH患者应用α-受体阻滞剂前后国际前列腺症状评分（IPSS）、生活质量评分（QOL）、最大尿流率（Qmax）、残余尿量（PVR）的变化。结果 两组患者年龄,应用α-受体阻滞剂前IPSS、QOL指标比较,差异无统计学意义（t=1.542、1.893、0.431,P〉0.05）,IPP显著组Qmax指标低于IPP非显著组,PVR指标高于IPP非显著组,两组比较差异有统计学意义（t=3.187、2.183,P〈0.05）。两组应用α-受体阻滞剂2个月后,IPP显著组IPSS前后改变值、QOL前后改变值均低于IPP非显著组,差异有统计学意义（t=2.799、5.116,P〈0.05）;Qmax和PVR改变值比较差异无统计学意义（t=1.919、0.852,P〉0.05）。结论 IPP可作为预测α-受体阻滞剂治疗BPH后IPSS、QOL变化的一个指标,为α-受体阻滞剂治疗BPH的临床效果评估提供参考。

Objective To explore the influence of intravesical prostatic protrusion （IPP） on application of a-blocker treated for patients with benign prostatic hyperplasia（BPH）. Methods From October 2012 to October 2015,clinical data from 168 BPH patients with IPP accepted a-blocker treatment in our hospital were retrospectively analyzed.According to degree of IPP,they were divided into significant IPP group （IPP〉5 mm,n=63） and non-significant IPP group （IPP 〈 5mm,n=10S）.The four indexes including international prostate symptom score （IPSS）,quality of life score （QOL）,maxi- mum urinary flow rate （Qmax）,and postvoid residual （PVR） before and after applying a-blockers in BPH patients in the two groups were studied and compared. Results There was no statistical difference in age,IPSS,and QOL before using a-blockers between two groups（t=1.542,1.893,0.431,P〉0.05）.The Qmax in the significant IPP group was lower than that in the non-significant IPP group and PVR in the significant IPP group was higher than the latter group,which were both displayed statistical differences （t =3.187,2.183,P〈0.05）.Two-month after applying or-blockers,value changes of IPSS and QOL score in the significant IPP group was lower than that in the non-significant IPP group respectively,with sta- tistical differences （t=2.799,5.116,P〈0.05）.There was no great difference in changes of Qmax or PVR （t=1.919,0.852,P〉 0.05）. Conclusion IPP can he considered as an indicator for predicting score changes of IPSS and QOL after applying a-blocker to treat BPH patients,which provides a clinical reference for clinical effect evaluation of BPH treated by a-blocker.