我院药品不良反应上报情况分析与评价

Analysis and evaluation of ADR reports in our hospital

目的 分析我院药品不良反应（ADR）发生的特点及规律,为临床合理用药提供参考。方法 对我院2015年上报的ADR报告进行分析、评价。结果 2015年我院共上报201例ADR。其中,一般的ADR 108例（53.7%）,新的一般的ADR 67例（33.3%）,严重的ADR 20例（10.0%）,新的严重的ADR 6例（3.0%）;男性患者90例（44.8%）,女性患者111例（55.2%）;40-79岁患者构成比最高;给药途径中以静脉滴注的比例最高（84.6%）;引起ADR发生率最高的药物为抗感染药（26.7%）;主要累及的系统/器官为皮肤及附件（37.3%）。结论 我院应进一步加强ADR的监管与防范,规范临床用药,加强患者用药宣传,确保用药安全。

Objective To analyze the characteristics,regularity of adverse drug reaction （ADR） reports so as to provide reference for the rational use of drugs in clinic. Methods ADR reports collected in Affiliated Hospital of North Sichuan Medical College in 2015 were analyzed and evaluated. Results There were 201 ADR reports collected in our hospital in 2015.Among the ADR reports,there were 108 cases （53.7%）common ADR,67 cases （33.3%） of new and common ADR,20 cases （10.0%） were severe ADR and 6 cases （3.0%） were new and severe ADR;90 cases （44.8%） were male and 111 cases （55.2%） were female;Patients aged from 40 to 79 years accounted for the largest proportion;The main admin- istration route causing ADR was intravenous infusion （84.6%）;The most frequency in suspected drugs was anti-infective drugs （26.7%）;Skin and appendages damage was the most frequent ADR （37.3%）. Conclusion Our hospital should strengthen ADR monitoring and prevention,clinical medication should be further standardized and the related knowl- edge of drugs should be publicized to ensure the patients＇ medication safety.