气滞胃痛颗粒治疗腹泻型肠易激综合征的疗效

Clinical efficacy of Qizhiweitong particles in treating diarrhea-predominant irritable bowel syndrome

目的观察气滞胃痛颗粒治疗腹泻型肠易激综合征的临床疗效。方法腹泻型肠易激综合征患者126例,随机分为治疗组和对照组,每组63例。两组均采用匹维溴铵片治疗;治疗组加用气滞胃痛颗粒。治疗4周后比较两组疗效。结果治疗后,两组患者的腹痛、腹泻、腹胀等临床症状均有改善,抑郁指数和焦虑指数均较治疗前降低(P<0.05)。治疗组腹胀及症状总积分较对照组降低(P<0.05);治疗组总有效率高于对照组(79.4%vs.55.6%)(P<0.05)。两组患者在治疗过程中均未发生严重不良反应。结论气滞胃痛颗粒联合匹维溴铵治疗腹泻型肠易激综合征疗效满意。

Objective To observe the clinical efficacy of Qizhiweitong particles in treating diarrhea-predominant irritable bowel syndrome（DPIBS）.Methods A total of 126 patients with DPIBS was equally randomized into two groups of A（treated with Qizhiweitong particles plus pinaverium bromide tablets）and B（treated with pinaverium bromide tablets alone）.Clinical efficacy was compared after treatment for 4 weeks.Results Compared to before,the symptoms of abdominal pain,diarrhea and abdominal distension were improved obviously and depression and anxiety indexes were decreased in both groups after treatment（P〈0.05）.The symptom score of group A was lower than that of group B（P〈0.05）.The overall effectiveness rate was higher in group A than that in group B（79.4% vs.55.6%）（P〈0.05）.No severe adverse effects were seen in both groups.Conclusion Qizhiweitong particles combined with pinaverium bromide tablets is more effective than pinaverium bromide tablets alone in treating the patients with DPIBS.