辛伐他汀与低分子肝素联合氯吡格雷治疗UAP患者的效果

Effect of simvastatin and low molecular weight heparin combined with clopidogrel in the treatment of patients with UAP

目的探讨辛伐他汀、低分子肝素联合氯吡格雷治疗不稳定性心绞痛(UAP)患者的临床效果。方法选取本院心血管内科收治的70例UAP患者,根据入院单双号分为试验组和对照组各35例,两组患者均给予辛伐他汀、低分子肝素及常规治疗,试验组加用氯吡格雷治疗,两组患者均连续用药4周,比较两组治疗效果。结果试验组治疗后的每周心绞痛发作次数、24 h心肌缺血发作次数、24 h心肌缺血总时间均显著的低于对照组(P<0.05)。治疗后两组患者的IL-6、hs-CRP、Hcy、NT-pro-BNP指标较本组治疗前均显著的降低(P<0.05),治疗后试验组的IL-6、hs-CRP水平显著的低于对照组(P<0.05)。试验组治疗的总有效率(88.57%)高于对照组(71.43%,P<0.05)。结论辛伐他汀、低分子肝素联合氯吡格雷治疗不稳定性心绞痛(UAP)患者具有更加显著的临床效果。

Objective To investigate the clinical effect of simvastatin and low molecular weight heparin combined with clopidogrel in the treatment of unstable angina（UAP）. Methods 70 cases of UAP patients were divided according to odd and even number of admission into the experimental group and control group, 35 cases each.Patients in both groups were given simvastatin, low molecular weight heparin and routine treatment; patients in experimental group were also treated with chlorine clopidogrel; patients were continuous treated for four weeks. Results Weekly angina episodes, 24 h episodes of myocardial ischemia, and myocardial ischemia 24 h total time of the experimental group were significantly lower than those of the control group（P 〈0.05）. In both groups, the levels of IL-6, hs-CRP, Hcy and NT-pro-BNP were significantly reduced after treatment;IL-6, hs-CRP levels of the experimental group after treatment were significantly lower than those of control group.（P 〈0.05）. The total efficiency of the experimental group（88.57%） was significantly higher than that of the control group（71.43%）（P 〈0.05）. Conclusion Simvastatin and low molecular weight heparin combined with clopidogrel in the treatment of unstable angina（UAP） patients have more significant clinical effect.