河南省某高校一起诺如病毒感染性腹泻暴发的病原学分析

Pathogenic analysis of an outbreak of infectious diarrhea by Norovirus in university in Henan Province

目的调查本次学校腹泻暴发的流行病学特征,查找主要危险因素,为进一步防控工作的开展提供依据。方法分别对病例,健康人对照和外环境进行采样,用核酸检测试剂进行病毒检测;SPSS 20.0软件进行差异性统计,不同率的比较用χ2检验。结果现场流行病学调查结果学生是高危人群（RR=29.84,95%CI：7.44~119.63）;实验室病毒学检测在291份样本中分离到诺如GⅡ型病毒阳性45份,其中病例阳性率明显高于对照（χ2=10.811,P=0.001）,提示诺如GⅡ型病毒为本次暴发的主要病原体;外环境样本检测结果提示同宿舍居住为可疑危险因素。结论本次疫情为诺如GⅡ型病毒感染性腹泻暴发,学生是高危人群,同宿舍居住为危险因素。

Objective To investigate the epidemiological characteristics of the diarrhea outbreaks in schools, and find the main risk factors, and provide the basis for further prevention and control of the disease. Methods Samples were obtained from the patients, healthy controls and environment for the detection of virus by PCR. Results The results of field epidemiological investigation indicated students were the high risk groups（RR =29.84,95% CI：7.44 ~119.63）. 45 out of 291 samples were detected the norovirus type G Ⅱ, and the detection rate was significantly higher than that of control（χ2=10.811,P =0.001）.It was suggested that the main pathogen of the outbreak was norovirus type G Ⅱ virus.From environmental samples test results prompted the same living quarters as suspicious risk factors. Conclusion It was confirmed the outbreak of diarrhea was caused by norovirus type G Ⅱ virus infectious, and students living in the same dormitory were at high risk.