凝血四项和D-二聚体检测对子痫前期的应用价值

The Application Value of Detection of Four Items of Coagulation Routine and D-Dimer in the Early Stage of Eclampsia

目的探讨检测凝血四项[凝血酶时间(TT)、部分凝血活酶时间(APTT)、凝血酶原时间(PT)和纤维蛋白原含量(FBG)]和D-二聚体(D-Dimer)在子痫前期(PE)的应用价值。方法检测67例PE孕妇、60例正常孕妇和70例非孕期妇女的凝血四项、D-Dimer和hs-CRP水平。结果观察组TT、PT时间和D-D水平高于对照组(P<0.05),APTT时间和FBG水平低于对照组(P<0.05);重度PE患者TT、PT时间和D-D水平高于轻度PE患者(P<0.05),APTT时间和FBG水平低于轻度PE患者(P<0.05)。结论子痫前期孕妇血液呈高凝状态,可能是发生子痫抽搐、MODS和DIC的病理生理基础,D-D水平可作为初步判断PE病情严重程度的指标之一。

Objective To discuss the application value of the detection of coagulation routine and D-Dimer for preeclampsia. Methods Detection of 67 cases in PE, 60 normal pregnant women and 70 non-pregnant women in coagulation routine and D-Dimer levels. Results The time of TT, PT and the level of D-dimer in observation group were higher than those in control group（P〈0.05）. The TT and PT time and the level of D-dimer of severe PE patients were higher than those of lowgrade PE patients（P〈0.05）. Conclusion The blood of pregnant women with preeclampsia is a high coagulation state, the pathological and physiological basis of eclampsia, MODS and DIC and the D-dimer level can be used as one of the indicators to judge the severity of PE.