布地奈德和盐酸氨溴索雾化吸入治疗毛细支气管炎的临床效果观察

Clinical Efficacy of Budesonide and Ambroxol Hhydrochloride Combination Inhalation Therapy in Bronchiolitis

目的探讨布地奈德和盐酸氨溴索雾化吸入治疗毛细支气管炎的临床疗效,为临床治疗儿童毛细支气管炎提供一定的临床借鉴。方法选取2013年1月～2015年12月于我院进行治疗的毛细支气管炎患儿160例为研究对象,随机分为观察组和对照组各80例。对照组给予α-糜蛋白酶3 mg、地塞米松2 mg加生理盐水20 ml超声雾化吸入,每天2次;观察组给予布地奈德混悬液0.5 mg、盐酸氨溴索7.5mg氧气驱动雾化吸入,每天2次,两组治疗疗程均为一周。两组治疗疗程结束后,治疗后观察两组患儿临床症状和体征改善情况。并记录两组患儿临床治疗有效率及不良反应发生率。结果经治疗后,观察组患儿临床症状消失时间级住院时间短于对照组,差异有统计学意义(P<0.05)。观察组总有效率为98.75%,高于对照组总有效率91.2%,差异有统计学意义(P<0.05);观察组不良反应发生率为1.25%,低于对照组5.00%,差异有统计学意义(P<0.05)。结论布地奈德和盐酸氨溴索雾化吸入治疗毛细支气管炎可有效缓解毛细支气管炎的临床症状,具有良好的临床疗效,不良反应发生率低。

Objective To investigate the efficacy of budesonide and ambroxol hydrochloride combination inhalation therapy in bronchiolitis. Methods160 children with bronchiolitis from January 2013 to December 2015 were randomly assigned to the control group and the observation group, each group 80 cases. The observation group were administered oxygen atomized inhalation of pulmicortrepule 0.5 mg, ambloxoi 15 mg and NS 2 ml twice a day, while the control group were treated with ultrasonic atomized inhalation ofα-chymotrpsin 3 mg, DXM 2 mg and NS 20 ml twice a day. The clinical symptoms were observed, and the effects and the adverse reaction rate were compared between the two groups. Results After treatment, the disappearing time of the clinical symptoms, wheezing rale and the mean therapy time of the treatment group were shorter than those of the control group （P〈0.05）. The total efifciency in the observation group was signiifcantly higher （P〈0.05）. The adverse reaction rate in the observation group was signiifcantly lower （P〈0.05）.Conclusion Budesonide and ambroxol hydrochloride combination inhalation therapy in bronchiolitis can signiifcantly improve the clinical symptoms, improve clinical effective, decrease the rate of adverse reaction.