CD141与CD36对甲状腺功能减退症患者外周血管内皮功能的影响

Effects of monocyte CD141 and platelet CD36 on peripheral vascular endothelial function in patients with hypothyroidism

目的:探讨单核细胞CD141及血小板CD36对甲状腺功能减退症患者(PWH)外周血管内皮功能的影响。方法:PWH组52例,40例健康体检者为对照组,流式细胞仪检测外周血单核细胞CD141及血小板CD36;彩色多普勒检测肱动脉血流介导的血管内皮舒张功能(FMD)。比较两组单核细胞表达CD141、血小板表达CD36的差异及FMD(%)的差异;Pearson法分析CD141及CD36与FMD(%)的相关性。结果:单核细胞CD141(%)PWH组为21.79±9.45,对照组为18.84±9.64,PWH组明显高于对照组(P<0.01);血小板CD36(%)PWH组为34.26±10.23,对照组为28.65±9.53,PWH组明显高于对照组(P<0.01)。FMD%PWH组为8.65±1.97,对照组为11.25±2.72,PWH组明显低于对照组(P<0.01)。CD141与FMD%存在负相关(r=-0.657,P<0.01);CD36与FMD%存在负相关(r=-0.557,P<0.01)。结论:PWH组单核细胞CD141及血小板CD36均明显高于对照组;CD141及CD36与血管内皮舒张功能均存在负相关。

Objective To investigate the effects of monocyte CD141 and platelet CD36 on peripheral vascular endothelial function（VEF） in patients with hypothyroidism（PWH）. Methods The number of monocyte CD141 and platelet CD36 from 52 patients wtih PWH and 40 healthy persons（control group） was calculated by flow cytometry. VEF was detected in terms of brachial artery flow-mediated dilatation（FMD） using Doppler ultrasonography. The differences of expressions of monocyte CD141 and platelet CD36 were compared between the two groups, so was FMD. The association of monocyte CD141 and platelet CD36 with FMD（%） was analyzed by Pearson analysis. Results Expression of monocyte CD141（%） was significantly higher in the PWH group than in the control group（21.79 ± 9.45 vs. 18.84 ± 9.64, P〈0.001）, so was expression of platelet CD36（%）（34.26 ± 10.23 vs. 28.65 ± 9.53, P〈0.001）. FMD% was lower in the PWH group than in the control group（8.65 ± 1.97 vs. 11.25 ± 2.72, P〈0.001）. CD141 was negatively correlated with FMD%（r =-0.657,P〈0.01）, so was CD36（r =-0.557, P〈0.01）. Conclusions Both monocyte CD141 and platelet CD36 are significantly higher in the PWH group than in the control group. CD141 and platelet CD36 are negatively related with VEF.