甲状腺乳头状癌浸润前沿磷酸化RB核质转位表达与淋巴结转移相关

Correlation of nuclear-cytoplasmic transport of p RB in the invasive front and lymph node metastasis in papillary thyroid carcinoma

目的:探讨甲状腺乳头状癌浸润前沿磷酸化RB(p RB)的表达及临床病理意义。方法:用免疫组织化学方法对82例加做颈部淋巴结清扫的部分或全部甲状腺手术切除标本进行p RB检测,分析p RB的表达及临床病理意义。结果:在甲状腺乳头状癌的浸润前沿,可见p RB以核质转位的模式表达,p RB在浸润前沿的核质转位表达是甲状腺乳头状癌淋巴结转移的独立预测因素。结论:浸润前沿p RB核质转位表达是甲状腺乳头状癌淋巴结转移的独立预测因素。

Objective To investigate the expression of phosphorylated RB（p RB） in the invasion front of papillary thyroid carcinoma and the clinical pathological implications. Methods Immunohistochemistry was applied in analyzing p RB expression feature and the clinical pathological implications in a total of 82 patients who underwent total or subtotal thyroidectomy and neck lymph node dissection for papillary thyroid carcinoma. Results The displacement of p RB proteins from the nucleus to the cytoplasm was observed in the invasive front of papillary thyroid carcinoma, which was an independent predictor of lymph node metastasis in papillary thyroid carcinoma. Conclusion Nuclear-cytoplasmic transport of p RB in the invasive front was an independent predictor of lymph node metastasis in papillary thyroid carcinoma.