摘要
目的分析214例无精子及少精子症患者的染色体核型和生殖激素水平,探讨男性不育患者的遗传学因素。方法采用外周血培养及G带染色分析214例无精子及少精子症患者的染色体核型,电化学发光法测定其血清生殖激素水平。结果染色体分析显示,染色体正常核型150例,占样本总量的70.09%;性染色体异核常型39例,占18.22%;染色体多态性变异21例,占9.81%;染色体平衡易位携带者4例,占1.87%。与染色体正常组相比,染色体异常组的卵泡刺激素(FSH)、黄体生成素(LH)和血清泌乳素(PRL)水平显著升高(P<0.05),T值呈降低趋势(P<0.05),E_2无显著性差异(P>0.05)。结论少精子及无精子症与染色体畸变及血清生殖激素异常密切相关,染色体核型及生殖激素的分析和检测,对临床不育症的诊治有指导意义。
Objective To analyze chromosome karyotype and reproductive hormones of 214 patients with azoospermia and oligospermia, and explore the genetic factors of male infertility. Methods Total of 214 cases of patients with azoospermia and oligospermia were recruited in the study, karyotype analysis was performed in peripheral blood lymphotytes using stand G-banding, and levels of reproductive hormones were detected by electrochemoluminescence method. Results G-banding showed that the number of normal chromosome karyotype was 150 cases, accounting for 70.09%; the number of abnormal sex chromosome karyotype was 39 cases, accounting for 18.22%; 21 cases of chromosome polymorphism variation, accounting for 9.81%;4 cases of chromosome balanced translocation carriers, accounting for 1.87%. levels of FSH, LH and PRL in chromosome abnormality group were higher than those in normal chromosome group(P〈0.05), T value showed a trend of drop(P〈0.05), and level of E2 had no significant change(P〉0.05). Conclusion Chromosome aberrations and reproductive hormones play an important roles in azoospermia and oligospermia. Analysis of chromosome karyotype and reproductive hormones can provide guidance for the diagnosis and treatment of infertility.
出处
《中国男科学杂志》
CAS
CSCD
2016年第3期38-41,共4页
Chinese Journal of Andrology
关键词
无精子症
少精子症
染色体
性腺甾类激素
azoospermia
oligospermia
chromosomes
gonadal steroid hormones